Expression of CXCR4 in definitive endoderm

Stable Identifier
R-HSA-9823950
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of CXCR4 in definitive endoderm
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mouse embryos, the chemokine receptor Cxcr4 is expressed in mesoderm and definitive endoderm, the two tissue types that are formed by ingression through the primitive streak (McGrath et al. 1999). Expression of Cxcr4 in mouse definitive endoderm later decreases at the stage when hindgut is formed (McGrath et al. 1999). NODAL signaling activates expression of CXCR4 through phosphorylated SMAD2 and SMAD3 (Brown et al. 2011). EOMES and GATA6, transcription factors expressed in the primitive streak and endoderm, also directly activate expression of CXCR4 (Chia et al. 2019).
Literature References
PubMed ID Title Journal Year
30629940 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Dunn, NR, Garcia-Bernardo, J, Chia, CY, Hattersley, AT, Madrigal, P, Vallier, L, Chhatriwala, M, Denil, SLIJ, El-Khairi, R, Shepherd, MH, Martinez, I

Stem Cell Reports 2019
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EOMES:p-2S-SMAD2,3:SMAD4:GATA6:CXCR4 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
Cite Us!