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NFE2 [nucleoplasm]
Stable Identifier
R-HSA-1008221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor NF-E2 45 kDa subunit, p45 NF-E2, NFE2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Expression of globin genes under control of the beta globin control region (Homo sapiens)
NF-E2:Promoter region of beta-globin [nucleoplasm] (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 binds the beta globin locus control region (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NF-E2:Promoter region of beta-globin [nucleoplasm] (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 is a heterodimer (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16621 NFE2
Gene Names
NFE2
Chain
chain:1-373
Reference Genes
BioGPS Gene:4778 NFE2
COSMIC (genes):NFE2 NFE2
CTD Gene:4778 NFE2
dbSNP Gene:4778 NFE2
ENSEMBL:ENSG00000123405 NFE2
HGNC:7780 NFE2
KEGG Gene (Homo sapiens):4778 NFE2
Monarch:4778 NFE2
NCBI Gene:4778 NFE2
OMIM:601490 NFE2
UCSC:Q16621 NFE2
Reference Transcript
RefSeq:NM_001136023.2 NFE2
RefSeq:NM_006163.2 NFE2
RefSeq:XM_005268906.4 NFE2
RefSeq:NM_001261461.1 NFE2
Other Identifiers
0003170014
11723881_a_at
16765525
209930_s_at
3456667
3456668
3456669
3456670
3456671
3456672
3456673
3456676
37179_at
4778
7963760
A_23_P13753
GE58812
GO:0000228
GO:0000790
GO:0000976
GO:0000981
GO:0000987
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006337
GO:0006355
GO:0006357
GO:0006950
GO:0007275
GO:0007596
GO:0007599
GO:0008150
GO:0009058
GO:0016605
GO:0030154
GO:0032991
GO:0032993
GO:0034641
GO:0042025
GO:0043226
GO:0043565
GO:0045652
GO:0045893
GO:0047485
GO:0048856
GO:0050699
GO:0051276
GO:1990837
ILMN_1711786
PH_hs_0004356
S77763_at
TC12001567.hg
g506817_3p_a_at
Participant Of
input
NFE2 is a heterodimer
hasComponent
NF-E2 [nucleoplasm]
output
NFE2 gene expression is stimulated by RUNX1:CBFB
Inferred To
nfe2 [nucleoplasm] (Danio rerio)
skn-1 [nucleoplasm] (Caenorhabditis elegans)
cnc [nucleoplasm] (Drosophila melanogaster)
Nfe2 [nucleoplasm] (Rattus norvegicus)
Transcription factor Nf-e2 45 kDa subunit [nucleoplasm] (Mus musculus)
NFE2 [nucleoplasm] (Bos taurus)
NFE2 [nucleoplasm] (Canis familiaris)
NFE2 [nucleoplasm] (Sus scrofa)
NFE2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001129495.1
,
NP_006154.1
,
NP_001248390.1
,
XP_005268963.1
OpenTargets
ENSG00000123405
HPA
ENSG00000123405-NFE2
GeneCards
Q16621
Ensembl
ENSG00000123405
,
ENSP00000397185
,
ENST00000553070
,
ENSP00000312436
,
ENSP00000439120
,
ENST00000435572
,
ENST00000540264
,
ENSP00000447558
,
ENST00000312156
PRO
Q16621
Orphanet
24758
PDB
2KZ5
,
1LVX
HMDB Protein
HMDBP02528
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:P22607 FGFR3
40
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 795fs*139 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
p-6Y-FGFR3 S371C [plasma membrane]
(R-HSA-2011886)
p-6Y-FGFR3 G370C [plasma membrane]
(R-HSA-2011883)
p-6Y-FGFR3 Y373C [plasma membrane]
(R-HSA-2011889)
p-6Y-FGFR3 795fs*139 [plasma membrane]
(R-HSA-2038360)
p-6Y-FGFR3 R248C [plasma membrane]
(R-HSA-2011884)
pY-FGFR3 [plasma membrane]
(R-HSA-2038368)
p-6Y-FGFR3 K650Q [plasma membrane]
(R-HSA-2032962)
p-6Y-FGFR3 K650N [plasma membrane]
(R-HSA-2032961)
p-6Y-FGFR3 K650E [plasma membrane]
(R-HSA-2032952)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853147)
p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853155)
p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853145)
p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853129)
p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853151)
p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853128)
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
0.556
3
UniProt:P06396 GSN
7
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [cytosol]
(R-HSA-5654207)
SPRED1 [plasma membrane]
(R-HSA-5658225)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.556
3
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