Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NFE2 [nucleoplasm]
Stable Identifier
R-HSA-1008221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor NF-E2 45 kDa subunit, p45 NF-E2, NFE2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Expression of globin genes under control of the beta globin control region (Homo sapiens)
NF-E2:Promoter region of beta-globin [nucleoplasm] (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 binds the beta globin locus control region (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NF-E2:Promoter region of beta-globin [nucleoplasm] (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 is a heterodimer (Homo sapiens)
NF-E2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
NFE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16621 NFE2
Gene Names
NFE2
Chain
chain:1-373
Reference Genes
BioGPS Gene:4778 NFE2
COSMIC (genes):NFE2 NFE2
CTD Gene:4778 NFE2
dbSNP Gene:4778 NFE2
ENSEMBL:ENSG00000123405 NFE2
HGNC:7780 NFE2
KEGG:hsa:4778 NFE2
Monarch:4778 NFE2
NCBI Gene:4778 NFE2
OMIM:601490 NFE2
UCSC:Q16621 NFE2
Reference Transcript
RefSeq:NM_001261461.1 NFE2
RefSeq:NM_001136023.2 NFE2
RefSeq:XM_005268906.4 NFE2
RefSeq:NM_006163.2 NFE2
Other Identifiers
11723881_a_at
16765525
209930_PM_s_at
209930_s_at
3456667
3456668
3456669
3456670
3456671
3456672
3456673
3456676
37179_at
4778
7963760
A_23_P13753
GE58812
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006325
GO:0006337
GO:0006355
GO:0006357
GO:0007599
GO:0010468
GO:0016605
GO:0032993
GO:0042802
GO:0043226
GO:0043565
GO:0045893
GO:0050699
GO:0080090
GO:0090575
GO:0140110
GO:0140467
GO:1990837
HMNXSV003039397
ILMN_1711786
PH_hs_0004356
S77763_at
TC12001567.hg
g506817_3p_a_at
Participates
as an input of
NFE2 is a heterodimer (Homo sapiens)
as a component of
NF-E2 [nucleoplasm] (Homo sapiens)
as an output of
NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
Inferred To
nfe2l3 [nucleoplasm]
(Danio rerio)
nfe2 [nucleoplasm]
(Xenopus tropicalis)
cnc [nucleoplasm]
(Drosophila melanogaster)
Nfe2 [nucleoplasm]
(Rattus norvegicus)
Homologues of NFE2 [nucleoplasm]
(Danio rerio)
Transcription factor Nf-e2 45 kDa subunit [nucleoplasm]
(Mus musculus)
nfe2l2b [nucleoplasm]
(Danio rerio)
NFE2 [nucleoplasm]
(Bos taurus)
NFE2 [nucleoplasm]
(Canis familiaris)
NFE2 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000312156
,
ENST00000553070
,
ENSP00000397185
,
ENSP00000312436
,
ENSP00000447558
,
ENST00000435572
,
ENSP00000439120
,
ENST00000540264
OpenTargets
ENSG00000123405
HPA
ENSG00000123405-NFE2
PRO
Q16621
Pharos - Targets
Q16621
GlyGen
Q16621
HMDB Protein
HMDBP02528
PDB
2KZ5
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4A8 NF2L3
0.623
4
UniProt:Q16621 NFE2
1
NFE2 [nucleoplasm]
(R-HSA-1008221)
0.623
2
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text