Reactome | NFE2 [nucleoplasm]

NFE2 [nucleoplasm]

Stable Identifier

R-HSA-1008221

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor NF-E2 45 kDa subunit, p45 NF-E2, NFE2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
        
        NFE2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16621 NFE2

Gene Names

NFE2

Chain

chain:1-373

Reference Genes

BioGPS Gene:4778 NFE2

COSMIC (genes):NFE2 NFE2

CTD Gene:4778 NFE2

dbSNP Gene:4778 NFE2

ENSEMBL:ENSG00000123405 NFE2

HGNC:7780 NFE2

KEGG Gene (Homo sapiens):4778 NFE2

Monarch:4778 NFE2

NCBI Gene:4778 NFE2

OMIM:601490 NFE2

UCSC:Q16621 NFE2

Reference Transcript

Other Identifiers

0003170014

11723881_a_at

16765525

209930_s_at

3456667

3456668

3456669

3456670

3456671

3456672

3456673

3456676

37179_at

4778

7963760

A_23_P13753

GE58812

GO:0000228

GO:0000790

GO:0000976

GO:0000981

GO:0000987

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006337

GO:0006355

GO:0006357

GO:0006950

GO:0007275

GO:0007596

GO:0007599

GO:0008150

GO:0009058

GO:0016605

GO:0030154

GO:0032991

GO:0032993

GO:0034641

GO:0042025

GO:0043226

GO:0043565

GO:0045652

GO:0045893

GO:0047485

GO:0048856

GO:0050699

GO:0051276

GO:1990837

ILMN_1711786

PH_hs_0004356

S77763_at

TC12001567.hg

g506817_3p_a_at

Participant Of

input

NFE2 is a heterodimer

hasComponent

NF-E2 [nucleoplasm]

output

NFE2 gene expression is stimulated by RUNX1:CBFB

Inferred To

nfe2 [nucleoplasm] (Danio rerio)

skn-1 [nucleoplasm] (Caenorhabditis elegans)

cnc [nucleoplasm] (Drosophila melanogaster)

Nfe2 [nucleoplasm] (Rattus norvegicus)

Transcription factor Nf-e2 45 kDa subunit [nucleoplasm] (Mus musculus)

NFE2 [nucleoplasm] (Bos taurus)

NFE2 [nucleoplasm] (Canis familiaris)

NFE2 [nucleoplasm] (Sus scrofa)

NFE2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001129495.1, NP_006154.1, NP_001248390.1, XP_005268963.1

OpenTargets

ENSG00000123405

HPA

ENSG00000123405-NFE2

GeneCards

Q16621

Ensembl

ENSG00000123405, ENSP00000397185, ENST00000553070, ENSP00000312436, ENSP00000439120, ENST00000435572, ENST00000540264, ENSP00000447558, ENST00000312156

PRO

Q16621

Orphanet

24758

PDB

2KZ5, 1LVX

HMDB Protein

HMDBP02528

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.556	3

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