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FGFR3 [plasma membrane]
Stable Identifier
R-HSA-2038357
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR3 in disease (Homo sapiens)
FGFR3 mutant receptor activation (Homo sapiens)
t(4;14) translocations of FGFR3 (Homo sapiens)
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)
FGFR3 (4;14) translocation mutant dimers [plasma membrane] (Homo sapiens)
Overexpressed FGFR3 mutant dimer [plasma membrane] (Homo sapiens)
FGFR3 [plasma membrane] (Homo sapiens)
Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)
FGFR3 (4;14) translocation mutant dimers [plasma membrane] (Homo sapiens)
Overexpressed FGFR3 mutant dimer [plasma membrane] (Homo sapiens)
FGFR3 [plasma membrane] (Homo sapiens)
FGFR3 (4;14) translocation mutants [plasma membrane] (Homo sapiens)
FGFR3 [plasma membrane] (Homo sapiens)
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
FGFR3 mutant dimers [plasma membrane] (Homo sapiens)
FGFR3 (4;14) translocation mutant dimers [plasma membrane] (Homo sapiens)
Overexpressed FGFR3 mutant dimer [plasma membrane] (Homo sapiens)
FGFR3 [plasma membrane] (Homo sapiens)
FGFR3 mutant dimers:TKIs [plasma membrane] (Homo sapiens)
FGFR3 mutant dimers [plasma membrane] (Homo sapiens)
FGFR3 (4;14) translocation mutant dimers [plasma membrane] (Homo sapiens)
Overexpressed FGFR3 mutant dimer [plasma membrane] (Homo sapiens)
FGFR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22607 FGFR3
Gene Names
FGFR3, JTK4
Chain
signal peptide:1-22, chain:23-806
Reference Genes
ENSEMBL:ENSG00000068078 FGFR3
Participates
as a candidate of
FGFR3 (4;14) translocation mutants [plasma membrane] (Homo sapiens)
as a component of
Overexpressed FGFR3 mutant dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
FGFR3 K650T [plasma membrane]
FGFR3 K650N [plasma membrane]
FGFR3 K650M [plasma membrane]
FGFR3 K650Q [plasma membrane]
FGFR3 A391E [plasma membrane]
FGFR3 K650E [plasma membrane]
FGFR3 G380R [plasma membrane]
FGFR3 G382D [plasma membrane]
FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 A391E [plasma membrane]
p-6Y-FGFR3 K650T [plasma membrane]
p-6Y-FGFR3 G382D [plasma membrane]
p-6Y-FGFR3 G380R [plasma membrane]
p-6Y-FGFR3 K650M [plasma membrane]
p-6Y-FGFR3 K650E [plasma membrane]
p-6Y-FGFR3 K650N [plasma membrane]
p-6Y-FGFR3 K650Q [plasma membrane]
pY-FGFR3 [plasma membrane]
p-6Y-FGFR3 R248C [plasma membrane]
p-6Y-FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 Y373C [plasma membrane]
p-4Y-FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
p-4Y-FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
p-6Y-FGFR3 G370C [plasma membrane]
p-6Y-FGFR3 S371C [plasma membrane]
FGFR3 R248C [plasma membrane]
FGFR3 G370C [plasma membrane]
FGFR3 Y373C [plasma membrane]
FGFR3 S371C [plasma membrane]
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.667
4
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.659
4
UniProt:Q7Z7J5 DPPA2
1
DPPA2 [nucleoplasm]
(R-HSA-9816401)
0.556
3
UniProt:Q9Y2Y0 ARL2BP
2
ARL2BP [cytosol]
(R-HSA-5215982)
ARL2BP [mitochondrial matrix]
(R-HSA-5250220)
0.556
3
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.556
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:Q99075 HBEGF
8
HBEGF(63-148) [clathrin-coated endocytic vesicle membrane]
(R-HSA-9628819)
HBEGF(20-208) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334782)
HBEGF(20-208) [endocytic vesicle membrane]
(R-HSA-5334776)
HB-EGF(161-208) [plasma membrane]
(R-HSA-9624270)
HBEGF(20-62) [extracellular region]
(R-HSA-2179390)
HBEGF(149-208) [extracellular region]
(R-HSA-2179391)
HBEGF(20-208) [plasma membrane]
(R-HSA-2179406)
HBEGF(63-148) [extracellular region]
(R-HSA-1233234)
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.556
3
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.556
3
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.556
3
UniProt:Q8N3R9 MPP5
2
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
MPP5 [plasma membrane]
(R-HSA-419969)
0.556
3
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.556
3
UniProt:Q99743 NPAS2
2
NPAS2 [cytosol]
(R-HSA-400314)
p-S-NPAS2 [nucleoplasm]
(R-HSA-421309)
0.556
3
UniProt:Q06323 PSME1
1
PSME1 [cytosol]
(R-HSA-68812)
0.556
3
UniProt:P55318 FOXA3
1
FOXA3 [nucleoplasm]
(R-HSA-211484)
0.556
3
UniProt:Q9NZH6 IL37
6
IL37(?-218) [extracellular region]
(R-HSA-9008607)
IL37 [extracellular region]
(R-HSA-8848334)
IL37(?-218) [cytosol]
(R-HSA-9008584)
IL37 [cytosol]
(R-HSA-9008596)
IL37(1-?) [cytosol]
(R-HSA-9008602)
IL37(?-218) [nucleoplasm]
(R-HSA-9008702)
0.556
3
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.556
3
UniProt:Q16621 NFE2
1
NFE2 [nucleoplasm]
(R-HSA-1008221)
0.556
3
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:Q9BVC3 DSCC1
1
DSCC1 [nucleoplasm]
(R-HSA-9668907)
0.556
3
UniProt:Q9UJU6 DBNL
7
DBNL [ficolin-1-rich granule lumen]
(R-HSA-6801510)
DBNL [tertiary granule lumen]
(R-HSA-6801516)
DBNL [extracellular region]
(R-HSA-6801604)
DBNL [secretory granule lumen]
(R-HSA-6801520)
DBNL(1-361) [cytosol]
(R-HSA-202925)
DBNL(362-431) [cytosol]
(R-HSA-202933)
DBNL [cytosol]
(R-HSA-202880)
0.556
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [endosome membrane]
(R-HSA-9631168)
CHMP7 [cytosol]
(R-HSA-917703)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.556
3
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.556
3
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
0.556
3
UniProt:Q6N021 TET2
1
TET2 [nucleoplasm]
(R-HSA-5221011)
0.556
3
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q9UBX5 FBLN5
1
FBLN5 [extracellular region]
(R-HSA-2161278)
0.556
3
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q86WV5 TEN1
1
TEN1 [nucleoplasm]
(R-HSA-9668823)
0.556
3
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.556
3
UniProt:Q15814 TBCC
1
TBCC [cytosol]
(R-HSA-379537)
0.556
3
UniProt:P22692 IGFBP4
5
IGFBP4 [extracellular region]
(R-HSA-381421)
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
0.556
3
UniProt:P62244 RPS15A
2
RPS15A [cytosol]
(R-HSA-72345)
RPS15A [nucleoplasm]
(R-HSA-6791191)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [nucleoplasm]
(R-HSA-606325)
ITGB3BP [cytosol]
(R-HSA-3006405)
0.556
3
UniProt:Q9H2A9 CHST8
1
CHST8 [Golgi membrane]
(R-HSA-6786024)
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.556
3
UniProt:O14641 DVL2
5
DVL2 [cytosol]
(R-HSA-201694)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.556
3
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.556
3
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.556
3
UniProt:A0AVK6 E2F8
1
E2F8 [nucleoplasm]
(R-HSA-8952990)
0.556
3
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