Reactome | ITGB3BP [nucleoplasm]

ITGB3BP [nucleoplasm]

Stable Identifier

R-HSA-606325

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Centromere protein R, CENPR_HUMAN

Icon

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Death Receptor Signalling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
      - NRIF signals cell death from the nucleus (Homo sapiens)
        
        Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)
        
        Ubiquitinated NRIF:Sequestosome [nucleoplasm] (Homo sapiens)
        
        ITGB3BP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13352 ITGB3BP

Gene Names

ITGB3BP, CENPR, NRIF3

Chain

chain:1-177

Reference Genes

BioGPS Gene:23421 ITGB3BP

COSMIC (genes):ITGB3BP ITGB3BP

CTD Gene:23421 ITGB3BP

dbSNP Gene:23421 ITGB3BP

ENSEMBL:ENSG00000142856 ITGB3BP

HGNC:6157 ITGB3BP

KEGG Gene (Homo sapiens):23421 ITGB3BP

Monarch:23421 ITGB3BP

NCBI Gene:23421 ITGB3BP

OMIM:605494 ITGB3BP

UCSC:Q13352 ITGB3BP

Reference Transcript

Other Identifiers

0001980044

11738703_a_at

11744511_x_at

11745297_x_at

205176_s_at

23421

2416219

2416220

2416223

2416225

2416234

2416235

2416236

2416242

2416245

2416246

2416249

2416250

2416252

38501_s_at

40676_at

7916727

A_23_P23765

GE59112

GO:0000775

GO:0000776

GO:0000777

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0006915

GO:0007049

GO:0007155

GO:0007165

GO:0008022

GO:0008150

GO:0008219

GO:0009058

GO:0016020

GO:0022607

GO:0034080

GO:0034641

GO:0043065

GO:0043226

GO:0051276

GO:0051301

GO:0065003

ILMN_1692790

PH_hs_0019190

PH_hs_0035905

U37139_at

g7657205_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

ITGB3BP [cytosol]

Inferred To

ITGB3BP [nucleoplasm] (Bos taurus)

ITGB3BP [nucleoplasm] (Gallus gallus)

Itgb3bp [nucleoplasm] (Mus musculus)

Itgb3bp [nucleoplasm] (Rattus norvegicus)

si:dkey-148h10.5 [nucleoplasm] (Danio rerio)

Ghost homologue of ITGB3BP [nucleoplasm] (Canis familiaris)

Ghost homologue of ITGB3BP [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_055103.3, NP_001193668.1, NP_001334077.1

OpenTargets

ENSG00000142856

HPA

ENSG00000142856-ITGB3BP

GeneCards

Q13352

Ensembl

ENSP00000432904, ENST00000489099, ENSG00000142856, ENSP00000271002, ENST00000271002, ENST00000371092, ENSP00000360133

PRO

Q13352

HMDB Protein

HMDBP01805

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.666	4
UniProt:Q9Y5P4 CERT1			0.666	4
UniProt:Q8WWB5 PIHD2			0.666	7
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:O75971-2 SNAPC5			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q9NWQ9 CN119			0.556	3
UniProt:Q5JVL4 EFHC1			0.556	3
UniProt:Q9H7Z3 NRDE2			0.556	3
UniProt:Q8N7C3 TRIMM			0.556	3
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:A0A024R8A9 A0A024R8A9			0.556	3
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:X5D778 X5D778			0.556	3
UniProt:A6NI15 MSGN1			0.556	3
UniProt:Q6ICG6-3 KIAA0930			0.556	3
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:O14770-4 MEIS2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3