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ITGB3BP [nucleoplasm]
Stable Identifier
R-HSA-606325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Centromere protein R, CENPR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Nucleosome assembly (Homo sapiens)
Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
HJURP:CENPA complex localizes to the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
Mis18 complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
RSF complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13352 ITGB3BP
Gene Names
ITGB3BP, CENPR, NRIF3
Chain
chain:1-177
Reference Genes
BioGPS Gene:23421 ITGB3BP
COSMIC (genes):ITGB3BP ITGB3BP
CTD Gene:23421 ITGB3BP
dbSNP Gene:23421 ITGB3BP
ENSEMBL:ENSG00000142856 ITGB3BP
HGNC:6157 ITGB3BP
KEGG:hsa:23421 ITGB3BP
Monarch:23421 ITGB3BP
NCBI Gene:23421 ITGB3BP
OMIM:605494 ITGB3BP
UCSC:Q13352 ITGB3BP
Reference Transcript
RefSeq:NM_001206739.2 ITGB3BP
RefSeq:NM_014288.4 ITGB3BP
RefSeq:NM_001347148.1 ITGB3BP
RefSeq:XM_047416576.1 ITGB3BP
RefSeq:XM_054335678.1 ITGB3BP
Participates
as a component of
CCAN [nucleoplasm] (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ITGB3BP [cytosol]
Inferred To
ITGB3BP [nucleoplasm]
(Bos taurus)
ITGB3BP [nucleoplasm]
(Canis familiaris)
ITGB3BP [nucleoplasm]
(Gallus gallus)
Itgb3bp [nucleoplasm]
(Mus musculus)
Itgb3bp [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of ITGB3BP [nucleoplasm]
(Sus scrofa)
Ghost homologue of ITGB3BP [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001334077.1
,
NP_001193668.1
,
NP_055103.3
,
XP_054191653.1
,
XP_047272532.1
OpenTargets
ENSG00000142856
ENSEMBL
ENST00000371092
,
ENST00000271002
,
ENSG00000142856
,
ENST00000489099
,
ENSP00000271002
,
ENSP00000432904
,
ENSP00000360133
GeneCards
ITGB3BP
HPA
ENSG00000142856-ITGB3BP
PRO
Q13352
Pharos - Targets
Q13352
GlyGen
Q13352
HMDB Protein
HMDBP01805
PDB
7YYH
,
7YWX
,
7XHO
,
7QOO
,
7R5S
,
7PKN
,
7R5V
,
7PB8
,
7XHN
Interactors (45)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q71F23 CENPU
2
MLF1IP [nucleoplasm]
(R-HSA-606309)
MLF1IP [cytosol]
(R-HSA-375315)
0.708
6
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.666
4
UniProt:Q9Y5P4 CERT1
0.666
4
UniProt:Q8WWB5 PIHD2
0.666
7
UniProt:Q7L2Z9 CENPQ
2
CENPQ [nucleoplasm]
(R-HSA-606327)
CENPQ [cytosol]
(R-HSA-375298)
0.643
4
UniProt:Q9BU64 CENPO
2
CENPO [nucleoplasm]
(R-HSA-606317)
CENPO [cytosol]
(R-HSA-375301)
0.643
5
UniProt:Q00613 HSF1
11
HSF1 [cytosol]
(R-HSA-3371452)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
HSF1 [nucleoplasm]
(R-HSA-5082385)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
0.556
3
UniProt:P14927 UQCRB
1
UQCRB [mitochondrial inner membrane]
(R-HSA-164287)
0.556
3
UniProt:Q969Y2 GTPBP3
1
GTPBP3 [mitochondrial matrix]
(R-HSA-6787414)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
UniProt:O14901 KLF11
0.556
6
UniProt:O14645 IDLC
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:X5D778 X5D778
0.556
3
UniProt:Q6ICG6-3 KIAA0930
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:P50440 GATM
1
GATM [mitochondrial intermembrane space]
(R-HSA-71267)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q96AL5 Q96AL5
0.556
3
UniProt:Q13449 LSAMP
2
cleaved GPI-LSAMP [extracellular region]
(R-HSA-8941032)
GPI-LSAMP [plasma membrane]
(R-HSA-8940809)
0.556
3
UniProt:P01112 HRAS
20
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
HRAS [plasma membrane]
(R-HSA-62717)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P62491 RAB11A
4
GGC-RAB11A [cytoplasmic vesicle membrane]
(R-HSA-1458519)
RAB11A [cytosol]
(R-HSA-5623395)
GGC-RAB11A [cytosol]
(R-HSA-8873781)
RAB11A [recycling endosome membrane]
(R-HSA-2029023)
0.556
3
UniProt:Q5JVL4 EFHC1
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:O75971-2 SNAPC5
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.556
3
UniProt:Q9BVL2 NUP58
0.556
6
UniProt:A6NI15 MSGN1
1
MSGN1 [nucleoplasm]
(R-HSA-9793376)
0.556
3
UniProt:P45984 MAPK9
3
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
MAPK9 [cytosol]
(R-HSA-450355)
0.556
3
UniProt:Q9Y2K6 USP20
1
USP20 [cytosol]
(R-HSA-5696946)
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:O14770-4 MEIS2
0.556
3
UniProt:Q8N7C3 TRIMM
0.556
3
UniProt:Q9H7Z3 NRDE2
0.556
3
UniProt:Q9NWQ9 CN119
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q6IPU0 CENPP
2
CENPP [nucleoplasm]
(R-HSA-606341)
CENPP [cytosol]
(R-HSA-375299)
0.527
4
UniProt:Q9H3R5 CENPH
2
CENPH [nucleoplasm]
(R-HSA-606314)
CENPH [cytosol]
(R-HSA-375294)
0.527
2
UniProt:Q96BT3 CENPT
2
CENPT [nucleoplasm]
(R-HSA-5633498)
CENPT [cytosol]
(R-HSA-375316)
0.527
2
UniProt:Q92674 CENPI
2
CENPI [cytosol]
(R-HSA-375293)
CENPI [nucleoplasm]
(R-HSA-606348)
0.527
2
UniProt:Q96H22 CENPN
2
CENPN [cytosol]
(R-HSA-375306)
CENPN [nucleoplasm]
(R-HSA-606336)
0.527
2
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