Reactome | POLR2E [cytosol]

POLR2E [cytosol]

Stable Identifier

R-HSA-1964438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HsRPABC1, DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (XAP4) (RPB5), DNA-directed RNA polymerase II 23 kDa polypeptide , RPB25, XAP4, RPB5, RPABC1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P19388 POLR2E

Gene Names

POLR2E

Chain

chain:1-210

Reference Genes

BioGPS Gene:5434 POLR2E

COSMIC (genes):POLR2E POLR2E

CTD Gene:5434 POLR2E

dbSNP Gene:5434 POLR2E

ENSEMBL:ENSG00000099817 POLR2E

ENSEMBL:ENSG00000099817.12 POLR2E

HGNC:9192 POLR2E

KEGG Gene (Homo sapiens):5434 POLR2E

Monarch:5434 POLR2E

NCBI Gene:5434 POLR2E

OMIM:180664 POLR2E

UCSC:P19388 POLR2E

Reference Transcript

RefSeq:NM_002695.3 POLR2E

Other Identifiers

11716271_at

11716272_a_at

11716273_x_at

11750008_a_at

11750009_x_at

16866565

213887_PM_s_at

213887_s_at

217854_PM_s_at

217854_s_at

3348058

3348070

3844953

3844954

3844955

3844956

3844957

3844958

3844959

3844960

3844961

3844962

3844963

3844964

3844965

3844966

3844970

3844974

41332_at

5434

8032149

84752_r_at

A_23_P165280

A_33_P3299829

A_33_P3299834

D38251_s_at

GO:0000428

GO:0001054

GO:0001055

GO:0001056

GO:0003677

GO:0003824

GO:0003899

GO:0005515

GO:0005634

GO:0005654

GO:0005665

GO:0005666

GO:0005730

GO:0005736

GO:0005829

GO:0006351

GO:0006360

GO:0006366

GO:0006383

GO:0016740

GO:0043226

GO:0050821

GO:0055029

GO:0140098

GO:1990062

HMNXSV003026961

Hs.24301.1.S1_3p_a_at

PH_hs_0031090

RNA95124|RNS_206_189

TC19000996.hg

Participates

as a component of

RNA Polymerase III Holoenzyme [cytosol] (Homo sapiens)

Other forms of this molecule

POLR2E [nucleoplasm]

Cross References

RefSeq

NP_002686.2

OpenTargets

ENSG00000099817

HPA

ENSG00000099817-POLR2E

GeneCards

P19388

Ensembl

ENSG00000099817, ENSP00000485021, ENST00000586746, ENST00000615234, ENSP00000464739, ENST00000612655, ENSP00000478303

PRO

P19388

Pharos - Targets

P19388

HMDB Protein

HMDBP11911

PDB

7A6H, 7AE1, 5IY6, 7OBA, 7OBB, 5IY7, 6O9L, 7AE3, 7LBM, 7DN3, 7D58, 7OB9, 6DRD, 7D59, 5IYC, 7FJJ, 8A43, 5IYD, 7FJI, 5IYB, 7AST, 7DU2, 7VBC, 7AEA, 5IYA, 7VBA, 7VBB, 6XRE, 5IY8, 5IY9

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.772	6
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.772	6
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.75	5
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.731	5
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.725	4
UniProt:Q9NVU0 POLR3E	2	POLR3E [nucleoplasm] (R-HSA-83706) POLR3E [cytosol] (R-HSA-1964451)	0.71	4
UniProt:P05423 POLR3D	2	POLR3D [nucleoplasm] (R-HSA-83704) POLR3D [cytosol] (R-HSA-1964429)	0.71	4
UniProt:O14802 POLR3A	2	POLR3A [nucleoplasm] (R-HSA-83700) POLR3A [cytosol] (R-HSA-1964433)	0.71	4
UniProt:Q9NW08 POLR3B	2	POLR3B [nucleoplasm] (R-HSA-83702) POLR3B [cytosol] (R-HSA-1964435)	0.71	4
UniProt:Q9Y2Y1 POLR3K	2	POLR3K [nucleoplasm] (R-HSA-1964461) POLR3K [cytosol] (R-HSA-1964455)	0.71	4
UniProt:P52434 POLR2H	2	POLR2H [nucleoplasm] (R-HSA-63523) POLR2H [cytosol] (R-HSA-1964450)	0.703	5
UniProt:P53803 POLR2K	2	POLR2K [nucleoplasm] (R-HSA-63537) POLR2K [cytosol] (R-HSA-1964445)	0.703	5
UniProt:O94763 RMP			0.669	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.655	5
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100)	0.648	4
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.648	4
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.648	5
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.648	4
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.643	3
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.643	5
UniProt:O75575 CRCP	2	CRCP [nucleoplasm] (R-HSA-5420844) CRCP [cytosol] (R-HSA-5420849)	0.621	3
UniProt:Q9Y535 POLR3H	2	POLR3H [nucleoplasm] (R-HSA-83710) POLR3H [cytosol] (R-HSA-1964440)	0.621	3
UniProt:P0DPB6 RPAC2			0.621	3
UniProt:O15318 POLR3G	2	POLR3G [nucleoplasm] (R-HSA-1964459) POLR3G [cytosol] (R-HSA-1964446)	0.621	3
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.621	3
UniProt:Q9H1D9 POLR3F	2	POLR3F [nucleoplasm] (R-HSA-83708) POLR3F [cytosol] (R-HSA-1964434)	0.621	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.621	3
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.569	3
UniProt:Q9GZS1 POLR1E	1	POLR1E [nucleoplasm] (R-HSA-5419294)	0.564	2
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.556	3
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.556	3
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	6
UniProt:Q92876 KLK6			0.556	3
UniProt:P00488 F13A1	4	factor XIIIa A chain [extracellular region] (R-HSA-140788) factor XIII A chain [extracellular region] (R-HSA-140600) factor XIII A chain activation peptide [extracellular region] (R-HSA-140790) F13A1(1-731) [platelet alpha granule lumen] (R-HSA-349759)	0.556	3
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.528	3
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.528	3
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	2
UniProt:Q9NWS0 PIHD1			0.527	2
UniProt:Q9H6T3 RPAP3			0.527	2
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.527	6
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.527	2
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.527	2
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	2
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.527	2
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.508	2
UniProt:Q15435 PP1R7			0.508	2
UniProt:O43156 TTI1			0.462	3

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