p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]

Stable Identifier
R-HSA-8853155
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
23175443 Oncogenic FGFR3 gene fusions in bladder cancer

Knowles, MA, Williams, SV, Hurst, CD

Hum. Mol. Genet. 2013
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Kalyana-Sundaram, S, Chinnaiyan, AM, Wang, R, Tomlins, SA, Ateeq, B, Cao, X, Cheng, AJ, Rhodes, DR, Hussain, MH, Kunju, LP, Lonigro, RJ, Robinson, DR, Sadis, S, Talpaz, M, Lin, SF, Pienta, KJ, Feng, FY, Roychowdhury, S, Vats, P, Wu, YM, Wyngaard, P, Su, F, Khazanov, N, Siddiqui, J, Zalupski, MM

Cancer Discov 2013
External Reference Information
External Reference
Gene Names
FGFR3, JTK4
Chain
signal peptide:1-22, chain:23-806
Other Identifiers
11717969_a_at
11755786_a_at
16964027
204379_PM_s_at
204379_s_at
204380_PM_s_at
204380_s_at
2261
2715017
2715018
2715019
2715026
2715027
2715028
2715029
2715030
2715031
2715032
2715033
2715039
2715040
2715041
2715042
2715043
2715045
2715046
2715047
2715048
2715049
2715051
2715053
2715054
2715056
2715057
2715058
31805_at
8093518
A_14_P132738
A_23_P212830
A_23_P500501
GE577766
GE58034
GO:0000165
GO:0000166
GO:0001501
GO:0001958
GO:0002062
GO:0003416
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005783
GO:0005794
GO:0005886
GO:0005925
GO:0006468
GO:0006629
GO:0006915
GO:0007169
GO:0007267
GO:0008284
GO:0008543
GO:0009986
GO:0010518
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017134
GO:0018108
GO:0023052
GO:0030133
GO:0030154
GO:0030282
GO:0031410
GO:0033674
GO:0035988
GO:0036211
GO:0042531
GO:0042802
GO:0043226
GO:0043235
GO:0043410
GO:0043552
GO:0046777
GO:0048640
GO:0048856
GO:0060089
GO:0060349
GO:0070374
GO:0070977
GO:0071363
GO:0140096
GO:1902178
HMNXSV003038877
ILMN_1651966
ILMN_1723123
M64347_at
TC04000029.hg
TC04001856.hg
g13112046_3p_a_at
g182568_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 647 to 838 at 761 from UniProt:Q9Y6A5 TACC3
Coordinate
761
Name
O4'-phospho-L-tyrosine at 577
Coordinate
577
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 647
Coordinate
647
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 648
Coordinate
648
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 724
Coordinate
724
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
Interactors (51)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P08238 HSP90AB1  6 0.667 4
 UniProt:O95674 CDS2  1 0.659 4
 UniProt:P01106 MYC  2 0.556 3
 UniProt:O14544 SOCS6  1 0.556 3
 UniProt:Q9UJU6 DBNL  7 0.556 3
 UniProt:Q13352 ITGB3BP  2 0.556 3
 UniProt:Q04206 RELA  6 0.556 3
 UniProt:Q99075 HBEGF  8 0.556 3
 UniProt:P17275 JUNB  1 0.556 3
 UniProt:Q00994 BEX3  1 0.556 3
 UniProt:P22415 USF1  1 0.556 3
 UniProt:Q9BXU0 TEX12  1 0.556 3
 UniProt:P23771 GATA3  2 0.556 3
 UniProt:Q9UKV8 AGO2  2 0.556 3
 UniProt:O14641 DVL2  5 0.556 3
 UniProt:Q99743 NPAS2  2 0.556 3
 UniProt:Q16621 NFE2  1 0.556 3
 UniProt:P24941 CDK2  5 0.556 3
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:A0AVK6 E2F8  1 0.556 3
 UniProt:Q86WV5 TEN1  1 0.556 3
 UniProt:O43504 LAMTOR5  1 0.556 3
 UniProt:Q8N3R9 MPP5  2 0.556 3
 UniProt:Q9H2A9 CHST8  1 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:O15534 PER1  4 0.556 3
 UniProt:Q8WUX9 CHMP7  2 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:P62333 PSMC6  2 0.556 3
 UniProt:Q7Z7J5 DPPA2  1 0.556 3
 UniProt:Q9Y2Y0 ARL2BP  2 0.556 3
 UniProt:Q8N5V2 NGEF  2 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:Q15814 TBCC  1 0.556 3
 UniProt:P19388 POLR2E  2 0.556 3
 UniProt:Q9NZH6 IL37  6 0.556 3
 UniProt:Q9BVC3 DSCC1  1 0.556 3
 UniProt:Q9UBX5 FBLN5  1 0.556 3
 UniProt:Q6NXG1 ESRP1  3 0.556 3
 UniProt:P62244 RPS15A  2 0.556 3
 UniProt:P38936 CDKN1A  5 0.556 3
 UniProt:Q06547-2 GABPB1  1 0.556 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.556 3
 UniProt:Q6N021 TET2  1 0.556 3
 UniProt:Q6IAA8 LAMTOR1  5 0.556 3
 UniProt:P22692 IGFBP4  5 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:P55318 FOXA3  1 0.556 3
 UniProt:P41134 ID1  1 0.556 3
 UniProt:P05412 JUN  4 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
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