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JUNB [nucleoplasm]
Stable Identifier
R-HSA-2186795
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor jun-B
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
JUNB dimer binds GZMB promoter (Homo sapiens)
GZMB gene:JUNB dimer [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB- and NPM1-ALK-mediated GZMB gene expression (Homo sapiens)
GZMB gene:JUNB dimer [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
NPM1-ALK-dependent JUNB translation (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
AP-1 binds ARC gene (Homo sapiens)
AP-1 dimers [nucleoplasm] (Homo sapiens)
FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
AP-1 dimers:ARC gene [nucleoplasm] (Homo sapiens)
AP-1 dimers [nucleoplasm] (Homo sapiens)
FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
ARC gene expression (Homo sapiens)
AP-1 dimers:ARC gene [nucleoplasm] (Homo sapiens)
AP-1 dimers [nucleoplasm] (Homo sapiens)
FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB, JUND [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
JUNB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17275 JUNB
Gene Names
JUNB
Chain
chain:1-347
Reference Genes
BioGPS Gene:3726 JUNB
COSMIC (genes):JUNB JUNB
CTD Gene:3726 JUNB
dbSNP Gene:3726 JUNB
ENSEMBL:ENSG00000171223 JUNB
HGNC:6205 JUNB
KEGG:hsa:3726 JUNB
Monarch:3726 JUNB
NCBI Gene:3726 JUNB
OMIM:165161 JUNB
UCSC:P17275 JUNB
Reference Transcript
RefSeq:NM_002229.2 JUNB
Other Identifiers
11715673_x_at
16858710
201473_PM_at
201473_at
2049_s_at
32786_at
3726
3821895
3821896
3821897
3821898
3821899
8026047
A_14_P128210
A_23_P4821
A_24_P241815
GE511331
GE86615
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001570
GO:0001649
GO:0001701
GO:0001829
GO:0002158
GO:0003677
GO:0003690
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006355
GO:0006357
GO:0022414
GO:0030154
GO:0030316
GO:0033687
GO:0035976
GO:0042127
GO:0043226
GO:0045597
GO:0045944
GO:0046697
GO:0048856
GO:0051726
GO:0060136
GO:0060716
GO:0071277
GO:0090575
GO:0140110
GO:0140467
GO:1990837
GO:2000319
HMNXSV003027341
ILMN_2086077
PH_hs_0030027
TC19000228.hg
TC19001995.hg
U20734_s_at
X51345_at
g4504808_3p_s_at
p33867
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
JUNB, JUND [nucleoplasm] (Homo sapiens)
FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
as an output of
NPM1-ALK-dependent JUNB translation (Homo sapiens)
SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
as an input of
JUNB dimer binds GZMB promoter (Homo sapiens)
as a component of
GZMB gene:JUNB dimer [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_002220.1
ENSEMBL
ENSP00000303315
OpenTargets
ENSG00000171223
HPA
ENSG00000171223-JUNB
PRO
P17275
Pharos - Targets
P17275
GlyGen
P17275
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16520 BATF
1
BATF [nucleoplasm]
(R-HSA-6789925)
0.965
45
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.94
14
UniProt:P15408 FOSL2
0.894
10
UniProt:Q9NR55 BATF3
0.876
9
UniProt:P15407 FOSL1
1
FOSL1 [nucleoplasm]
(R-HSA-9620405)
0.855
11
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.829
7
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.764
6
UniProt:P53539 FOSB
1
FOSB [nucleoplasm]
(R-HSA-9009922)
0.742
8
UniProt:Q8N1L9 BATF2
0.676
5
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.643
3
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.623
2
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.622
3
UniProt:Q6FG41 Q6FG41
0.601
4
UniProt:P17544 ATF7
0.59
4
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:Q8WYK2 JDP2
0.547
3
UniProt:P17535 JUND
1
JUND [nucleoplasm]
(R-HSA-9009924)
0.527
2
UniProt:Q7L5Y6 DET1
1
DET1 [cytosol]
(R-HSA-976007)
0.527
2
UniProt:Q9H9Q2 COPS7B
2
COPS7B [nucleoplasm]
(R-HSA-5697023)
COPS7B [cytosol]
(R-HSA-416966)
0.527
2
UniProt:Q9NS91 RAD18
1
RAD18 [nucleoplasm]
(R-HSA-5643731)
0.527
2
UniProt:Q8N2I9 STK40
0.527
2
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
2
UniProt:Q86XI8 ZSWM9
0.524
2
UniProt:P56279 TCL1A
0.524
2
IntAct:EBI-10046032 CCR4
0.499
4
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