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NFKBIB [cytosol]
Stable Identifier
R-HSA-168132
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IkBB, NF-kappaB inhibitor beta
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:IkB [cytosol] (Homo sapiens)
IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:IKB [cytosol] (Homo sapiens)
IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p65:p65:IKB [cytosol] (Homo sapiens)
IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
NFkB inhibitor:NFkB complex [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
NFKBIB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15653 NFKBIB
Gene Names
NFKBIB, IKBB, TRIP9
Chain
chain:1-356
Reference Genes
BioGPS Gene:4793 NFKBIB
COSMIC (genes):NFKBIB NFKBIB
CTD Gene:4793 NFKBIB
dbSNP Gene:4793 NFKBIB
ENSEMBL:ENSG00000104825 NFKBIB
ENSEMBL_homo_sapiens_GENE:ENSG00000104825.17 NFKBIB
ENSEMBL_homo_sapiens_GENE:ENSG00000282905.2 NFKBIB
HGNC:7798 NFKBIB
KEGG Gene (Homo sapiens):4793 NFKBIB
Monarch:4793 NFKBIB
NCBI Gene:4793 NFKBIB
OMIM:604495 NFKBIB
UCSC:Q15653 NFKBIB
Reference Transcript
RefSeq:NM_001243116.1 NFKBIB
RefSeq:NM_002503.4 NFKBIB
Other Identifiers
11725835_at
11725836_x_at
11745604_x_at
11745832_a_at
16861895
214062_3p_x_at
214062_PM_x_at
214062_x_at
214448_3p_x_at
214448_PM_x_at
214448_x_at
228388_3p_at
228388_PM_at
228388_at
3832763
3832764
3832765
3832767
3832768
3832769
3832770
3832771
3832772
3832773
3832774
41065_at
43069_at
4793
8028552
A_23_P330895
A_23_P79086
A_24_P161086
A_33_P3343545
GE81164
GE87209
GO:0003713
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006954
GO:0007165
GO:0023052
GO:0043122
GO:0043226
GO:0045893
GO:0071222
GO:0140110
HMNXSV003016327
HMNXSV003028472
HMNXSV003035878
Hs.9731.0.S1_3p_a_at
Hs.9731.0.S1_3p_at
Hs.9731.0.S1_3p_x_at
Hs.9731.1.S1_3p_a_at
Hs.9731.1.S1_3p_x_at
ILMN_1674152
ILMN_1712754
L40407_at
PH_hs_0030976
TC19000534.hg
TC19002129.hg
p34312
Participates
as a member of
IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
NFkB inhibitor [cytosol] (Homo sapiens)
Other forms of this molecule
p-S19,S23-Ub-NFKBIB [cytosol]
p-S19,S23-NFKBIB [cytosol]
Inferred To
nfkbib [cytosol]
(Danio rerio)
NFKBIB [cytosol]
(Bos taurus)
NFKBIB [cytosol]
(Canis familiaris)
NFKBIB [cytosol]
(Gallus gallus)
NFKBIB [cytosol]
(Sus scrofa)
Nfkbib [cytosol]
(Mus musculus)
Nfkbib [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001230045.1
,
NP_002494.2
OpenTargets
ENSG00000104825
HPA
ENSG00000104825-NFKBIB
GeneCards
Q15653
Ensembl
ENST00000572515
,
ENST00000313582
,
ENSP00000489145
,
ENSP00000459728
,
ENST00000634647
,
ENSP00000312988
,
ENSG00000104825
,
ENSG00000282905
,
ENSP00000489138
,
ENST00000635517
PRO
Q15653
Pharos - Targets
Q15653
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.85
9
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.763
6
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.564
4
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.564
2
UniProt:P20226 TBP
1
TBP [nucleoplasm]
(R-HSA-83718)
0.564
3
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.564
2
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.564
3
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.564
2
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.564
2
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