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IKBIP [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-9749482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
IKIP, Inhibitor of nuclear factor kappa-B kinase-interacting protein
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
TP53 stimulates IKBIP gene expression (Homo sapiens)
IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q70UQ0 IKBIP
Gene Names
IKBIP, IKIP
Chain
chain:1-350
Reference Genes
BioGPS Gene:121457 IKBIP
COSMIC (genes):IKBIP IKBIP
CTD Gene:121457 IKBIP
dbSNP Gene:121457 IKBIP
ENSEMBL:ENSG00000166130 IKBIP
ENSEMBL_homo_sapiens_GENE:ENSG00000166130.15 IKBIP
HGNC:26430 IKBIP
KEGG Gene (Homo sapiens):121457 IKBIP
Monarch:121457 IKBIP
NCBI Gene:121457 IKBIP
OMIM:609861 IKBIP
UCSC:Q70UQ0 IKBIP
Reference Transcript
RefSeq:NM_201612.2 IKBIP
RefSeq:NM_201613.2 IKBIP
RefSeq:NM_153687.3 IKBIP
Other Identifiers
11726779_a_at
11728427_at
11758567_s_at
121457
16768941
227295_PM_at
227295_at
235202_PM_x_at
235202_x_at
236249_PM_at
236249_at
3467316
3467317
3467318
3467322
3467323
3467324
3467325
3467326
3467327
3467328
3467329
3467334
3467335
3467336
3467337
3467338
3467339
46658_at
76789_at
7965681
83300_at
83331_at
A_23_P303210
A_23_P53467
GE544100
GO:0005515
GO:0005634
GO:0005730
GO:0005783
GO:0005789
GO:0010165
GO:0016020
GO:0043226
HMNXSV003004000
HMNXSV003041578
Hs.134156.0.A1_3p_at
Hs.152484.0.A1_3p_at
Hs.152484.0.A1_3p_x_at
Hs.71523.0.A1_3p_at
ILMN_1701402
ILMN_2324989
ILMN_2324994
PH_hs_0019254
TC12001861.hg
Participates
as an output of
TP53 stimulates IKBIP gene expression (Homo sapiens)
as a component of
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
IKBIP binds IKBKB and CHUK (Homo sapiens)
Inferred To
IKBIP [endoplasmic reticulum membrane]
(Bos taurus)
Cross References
RefSeq
NP_710154.1
,
NP_963907.1
,
NP_963906.1
OpenTargets
ENSG00000166130
GeneCards
Q70UQ0
HPA
ENSG00000166130-IKBIP
Ensembl
ENSP00000343471
,
ENST00000299157
,
ENST00000393042
,
ENSP00000376762
,
ENSG00000166130
,
ENSP00000299157
,
ENST00000342502
PRO
Q70UQ0
Pharos - Targets
Q70UQ0
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15173 MYOG
1
MYOG [nucleoplasm]
(R-HSA-445160)
0.666
4
UniProt:Q5VU62 Q5VU62
0.556
3
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.556
3
UniProt:P37198 NUP62
2
NUP62 [cytosol]
(R-HSA-9634226)
NUP62 [nuclear envelope]
(R-HSA-157713)
0.556
3
UniProt:Q9BUW7 BBLN
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
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