Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-S177,S181-IKBKB [cytosol]
Stable Identifier
R-RNO-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q9QY78
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Downstream signaling events of B Cell Receptor (BCR) (Rattus norvegicus)
Activation of NF-kappaB in B cells (Rattus norvegicus)
Activated IKK phosphorylates I-kappaB (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Activation of IKK complex (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Cytosolic sensors of pathogen-associated DNA (Rattus norvegicus)
ZBP1(DAI) mediated induction of type I IFNs (Rattus norvegicus)
RIP-mediated NFkB activation via ZBP1 (Rattus norvegicus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Rattus norvegicus)
TRAF6 mediated NF-kB activation (Rattus norvegicus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated NF-kB activation (Rattus norvegicus)
Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
Phospho-IKK-beta homdimer [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9QY78
Reference Genes
BioGPS Gene:84351
ENSEMBL:ENSRNOG00000019073
KEGG Gene (Rattus norvegicus):84351
Monarch:84351
NCBI Gene:84351
UCSC:Q9QY78
Reference Transcript
RefSeq:NM_053355.2
Participates
as a component of
Phospho-IKK-beta homdimer [cytosol] (Rattus norvegicus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Rattus norvegicus)
Other forms of this molecule
IKBKB [cytosol]
Inferred From
p-S177,S181-IKBKB [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 177 (in Homo sapiens)
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 181 (in Homo sapiens)
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_445807.2
PRO
Q9QY78
RGD
621375
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O70377
4
phospho-Snap23 [phagocytic vesicle membrane]
(R-RNO-8863923)
Snap23 [specific granule membrane]
(R-RNO-6806157)
Snap23 [plasma membrane]
(R-RNO-376345)
Snap23 [tertiary granule membrane]
(R-RNO-6806141)
0.524
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text