Reactome | CD4 [clathrin-coated endocytic vesicle membrane]

CD4 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01730 CD4

Gene Names

CD4

Chain

signal peptide:1-25, chain:26-458

Reference Genes

BioGPS Gene:920 CD4

COSMIC (genes):CD4 CD4

CTD Gene:920 CD4

dbSNP Gene:920 CD4

ENSEMBL:ENSG00000010610 CD4

HGNC:1678 CD4

KEGG:hsa:920 CD4

Monarch:920 CD4

NCBI Gene:920 CD4

OMIM:186940 CD4

UCSC:P01730 CD4

Reference Transcript

RefSeq:NM_000616.4 CD4

Other Identifiers

1146_at

11738979_x_at

11738980_a_at

11738981_x_at

11738982_at

11750157_at

16747417

203547_PM_at

203547_at

3402787

3402788

3402790

3402791

3402793

3402794

3402795

3402798

3402799

3402800

3402801

3402802

3402803

3402804

3402805

3402807

3402810

3402811

3402812

3402813

3402815

35517_at

48538_at

7953428

920

A_14_P100337

A_14_P109852

A_21_P0000664

A_24_P295999

GE61155

GE84064

GO:0001618

GO:0001934

GO:0002250

GO:0002376

GO:0004888

GO:0005198

GO:0005201

GO:0005515

GO:0005768

GO:0005769

GO:0005788

GO:0005789

GO:0005886

GO:0006355

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0008270

GO:0008289

GO:0009897

GO:0009986

GO:0015026

GO:0016020

GO:0019722

GO:0019899

GO:0019901

GO:0023026

GO:0030154

GO:0030217

GO:0030225

GO:0030669

GO:0031410

GO:0032507

GO:0032743

GO:0033674

GO:0035397

GO:0035723

GO:0038023

GO:0042011

GO:0042012

GO:0042101

GO:0042110

GO:0042289

GO:0042802

GO:0042803

GO:0043123

GO:0043226

GO:0043410

GO:0045058

GO:0045121

GO:0045657

GO:0045860

GO:0045893

GO:0046598

GO:0046718

GO:0050731

GO:0050829

GO:0050850

GO:0050863

GO:0050870

GO:0051924

GO:0060089

GO:0070374

GO:0097011

GO:0098542

GO:1990782

HMNXSV003005320

HMNXSV003009618

HMNXSV003037992

Hs.17483.0.S2_3p_at

ILMN_1727284

PH_hs_0001579

PH_hs_0040481

TC12000092.hg

TC12002205.hg

Participates

as a member of

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

CD4 [plasma membrane]

CD4 [endoplasmic reticulum membrane]

CD4 [early endosome]

Inferred To

Cd4 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Cd4 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

CD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

CD4 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CD4 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Cross References

RefSeq

NP_000607.1

Guide to Pharmacology - Targets

2995

OpenTargets

ENSG00000010610

ENSEMBL

ENSP00000011653, ENST00000011653

HPA

ENSG00000010610-CD4

ZINC - Substances

CD4_HUMAN

ZINC target

P01730

PRO

P01730

Pharos - Targets

P01730

GlyGen

P01730

ZINC - Predictions - Purchasable

CD4_HUMAN

PDB

3CD4, 8FYJ, 6L1Y, 3JCB, 3JWO, 3JCC, 6U0L, 4H8W, 2NXY, 2B4C, 4Q6I, 5A7X, 1Q68, 8D5C, 1GC1, 6OPQ, 6X5C, 6OPP, 6OPO, 6QH6, 3S5L, 4P9H, 2NY0, 2NY4, 2NY2, 6MEO, 3O2D, 7T0O, 2KLU, 5VN3, 7TXD, 1CDI, 2NY5, 1CDH, 2NY6, 5CAY, 1WIP, 1G9N, 1CDY, 2QAD, 5U1F, 1JL4, 6X5B, 3S4S, 6OPN, 8FYI, 2NXZ, 5THR, 1WBR, 4R4H, 1CDJ, 3JWD, 6QH7, 6CM3, 3B71, 3J70, 5A8H, 6U0N, 2JKR, 4JM2, 2NY3, 2NY1, 6MET, 3LQA, 7T0R, 6URI, 1RZJ, 1RZK, 6EDU, 3T0E, 4R2G, 1WIQ, 1WIO, 1G9M, 4RQS, 2JKT, 1CDU

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.702	3
UniProt:P51681 CCR5	1	CCR5 [plasma membrane] (R-HSA-171279)	0.667	3
UniProt:Q2N0S6 Q2N0S6			0.618	3
UniProt:P04578-PRO_0000038427 ENV			0.618	3
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.558	2
UniProt:P03407 NEF			0.558	2
UniProt:P01730 CD4	4	CD4 [plasma membrane] (R-HSA-167542) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [early endosome] (R-HSA-182147) CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082)	0.558	2
UniProt:Q1PHM6 Q1PHM6			0.558	2
UniProt:P13473-2 P134732			0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q9NPF0 CD320	2	CD320 [plasma membrane] (R-HSA-2980909) CD320 E88del [plasma membrane] (R-HSA-3325560)	0.527	2
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.527	2
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.527	2
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:A6NKD9 CC85C			0.527	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.524	3

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