Reactome | CD4 [plasma membrane]

CD4 [plasma membrane]

Stable Identifier

R-HSA-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - AP-2 directly binds some endocytic cargo (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)
        
        CD4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01730 CD4

Gene Names

CD4

Chain

signal peptide:1-25, chain:26-458

Reference Genes

BioGPS Gene:920 CD4

COSMIC (genes):CD4 CD4

CTD Gene:920 CD4

dbSNP Gene:920 CD4

ENSEMBL:ENSG00000010610.10 CD4

HGNC:1678 CD4

KEGG Gene (Homo sapiens):920 CD4

Monarch:920 CD4

NCBI Gene:920 CD4

OMIM:186940 CD4

UCSC:P01730 CD4

Reference Transcript

RefSeq:NM_000616.4 CD4

Other Identifiers

1146_at

11738979_x_at

11738980_a_at

11738981_x_at

11738982_at

11750157_at

16747417

203547_PM_at

203547_at

3402787

3402788

3402790

3402791

3402793

3402798

3402800

3402801

3402802

3402803

3402804

3402807

3402810

3402811

3402812

3402813

3402815

35517_at

48538_at

7953428

920

A_14_P100337

A_24_P295999

GE61155

GO:0001618

GO:0001934

GO:0002250

GO:0002376

GO:0004888

GO:0005198

GO:0005201

GO:0005515

GO:0005768

GO:0005769

GO:0005783

GO:0005788

GO:0005789

GO:0005886

GO:0006351

GO:0006355

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0008270

GO:0008289

GO:0009897

GO:0009986

GO:0015026

GO:0016020

GO:0016021

GO:0018108

GO:0019722

GO:0019899

GO:0019901

GO:0023026

GO:0023052

GO:0030154

GO:0030217

GO:0030225

GO:0030669

GO:0031410

GO:0032507

GO:0032743

GO:0033674

GO:0035397

GO:0035723

GO:0036211

GO:0038023

GO:0042011

GO:0042012

GO:0042101

GO:0042110

GO:0042289

GO:0042802

GO:0042803

GO:0043123

GO:0043226

GO:0043410

GO:0045058

GO:0045121

GO:0045657

GO:0045860

GO:0045893

GO:0046598

GO:0046718

GO:0048856

GO:0050731

GO:0050829

GO:0050850

GO:0050863

GO:0050870

GO:0050896

GO:0051924

GO:0060089

GO:0070374

GO:0097011

GO:0098542

GO:1990782

HMNXSV003005320

HMNXSV003009618

Hs.17483.0.S2_3p_at

ILMN_1727284

PH_hs_0001579

TC12000092.hg

TC12002205.hg

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

CD4 [clathrin-coated endocytic vesicle membrane]

CD4 [early endosome]

CD4 [endoplasmic reticulum membrane]

Inferred To

Cd4 [plasma membrane] (Mus musculus)

Cd4 [plasma membrane] (Rattus norvegicus)

CD4 [plasma membrane] (Bos taurus)

CD4 [plasma membrane] (Canis familiaris)

CD4 [plasma membrane] (Danio rerio)

CD4 [plasma membrane] (Gallus gallus)

CD4 [plasma membrane] (Sus scrofa)

CD4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000607.1

Guide to Pharmacology - Targets

2995

OpenTargets

ENSG00000010610

ZINC - Substances

CD4_HUMAN

ZINC target

P01730

PRO

P01730

PDB

3S4S, 5THR, 4R4H, 3T0E, 3JCB, 4P9H, 1CDU, 1CDY, 3J70, 1WBR, 3JWD, 7T0O, 2KLU, 6QH7, 5A7X, 3JWO, 6MET, 2NXZ, 3S5L, 2NY1, 6MEO, 7T0R, 4Q6I, 6X5B, 1CDH, 6L1Y, 6EDU, 5U1F, 1WIO, 5VN3, 1Q68, 4H8W, 6QH6, 1WIP, 4R2G, 2B4C, 6U0L, 1CDJ, 8D5C, 1WIQ, 6OPN, 1G9N, 6OPO, 2NY6, 1G9M, 2NXY, 5CAY, 3CD4, 6CM3, 4JM2, 6U0N, 1JL4, 6OPQ, 2NY0, 6OPP, 2NY3, 5A8H, 2QAD, 2JKT, 1RZJ, 2JKR, 4RQS, 3LQA, 2NY2, 3JCC, 1RZK, 6X5C, 1GC1, 3B71, 1CDI, 2NY4, 6URI, 3O2D, 2NY5

HPA

ENSG00000010610-CD4

GeneCards

P01730

Ensembl

ENST00000011653, ENSP00000011653, ENSG00000010610

Pharos - Targets

P01730

Orphanet

28719

ZINC - Predictions - Purchasable

CD4_HUMAN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.702	3
UniProt:P51681 CCR5	1	CCR5 [plasma membrane] (R-HSA-171279)	0.667	3
UniProt:P04578-PRO_0000038427 ENV			0.618	3
UniProt:Q2N0S6 Q2N0S6			0.618	3
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.558	2
UniProt:P03407 NEF			0.558	2
UniProt:Q1PHM6 Q1PHM6			0.558	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.558	2
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P05919 vpu	6	VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.524	3

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