Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
AKT phosphorylates TSC2, inhibiting it
Show undefined attributes
Go to Details
authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity
[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
dbId
198609
diseaseReaction
[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens
displayName
AKT phosphorylates TSC2, inhibiting it
edited
[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf
[Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol - Homo sapiens
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent
[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[EntityWithAccessionedSequence:R-HSA-2980548] TSC2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199381] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
[LiteratureReference:199857] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
maxDepth
1
modified
[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name
AKT phosphorylates TSC2, inhibiting it
orthologousEvent
[Reaction:R-SPO-198609] AKT phosphorylates TSC2, inhibiting it - Schizosaccharomyces pombe
[Reaction:R-DDI-198609] AKT phosphorylates TSC2, inhibiting it - Dictyostelium discoideum
[Reaction:R-DME-198609] AKT phosphorylates TSC2, inhibiting it - Drosophila melanogaster
[Reaction:R-GGA-198609] AKT phosphorylates TSC2, inhibiting it - Gallus gallus
[Reaction:R-RNO-198609] AKT phosphorylates TSC2, inhibiting it - Rattus norvegicus
[Reaction:R-MMU-198609] AKT phosphorylates TSC2, inhibiting it - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[EntityWithAccessionedSequence:R-HSA-199484] p-S939,T1462-TSC2 [cytosol]
precedingEvent
[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
releaseDate
2008-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-198609
summation
[Summation:199479] AKT phosphorylates and inhibits TSC2 (tuberin), a suppressor...
updateTrackers
[UpdateTracker:9785149] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v52:[modifyText]
[UpdateTracker:9783566] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v56:[modifyText]
[UpdateTracker:9788488] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v42:[modifyText]
[UpdateTracker:9787731] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
[UpdateTracker:9789180] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v38:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9785149] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v52:[modifyText]
[UpdateTracker:9783566] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v56:[modifyText]
[UpdateTracker:9788488] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v42:[modifyText]
[UpdateTracker:9787731] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
[UpdateTracker:9789180] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v38:[modifyText]
(normalReaction)
[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it
(hasEvent)
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
[Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol
(precedingEvent)
[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text