Reactome | G6PD multimers dehydrogenate G6P

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G6PD multimers dehydrogenate G6P Show undefined attributes

authored	[InstanceEdit:73679] D'Eustachio, P, 2003-06-25 00:00:00
catalystActivity	[CatalystActivity:70374] glucose-6-phosphate dehydrogenase activity of G6PD dimer and tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643648] glucose-6-phosphate dehydrogenase activity of G6PD dimer and tetramer [cytosol] Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9925927] RHEA:15842
dbId	70377
deleted	[Deleted:464978] Deletion of instance: 71293
displayName	G6PD multimers dehydrogenate G6P
edited	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
eventOf	[Pathway:R-HSA-71336] Pentose phosphate pathway - Homo sapiens [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate - Homo sapiens [Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-30537] G6P [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199808] Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants [LiteratureReference:464976] Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency [LiteratureReference:8855808] Glucose-6-phosphate dehydrogenase: a biomarker and potential therapeutic target for cancer
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	G6PD multimers dehydrogenate G6P alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
orthologousEvent	[Reaction:R-PFA-70377] G6PD multimers dehydrogenate G6P - Plasmodium falciparum [Reaction:R-SCE-70377] G6PD multimers dehydrogenate G6P - Saccharomyces cerevisiae [Reaction:R-SPO-70377] G6PD multimers dehydrogenate G6P - Schizosaccharomyces pombe [Reaction:R-DDI-70377] G6PD multimers dehydrogenate G6P - Dictyostelium discoideum [Reaction:R-CEL-70377] G6PD multimers dehydrogenate G6P - Caenorhabditis elegans [Reaction:R-DME-70377] G6PD multimers dehydrogenate G6P - Drosophila melanogaster [Reaction:R-XTR-70377] G6PD multimers dehydrogenate G6P - Xenopus tropicalis [Reaction:R-SSC-70377] G6PD multimers dehydrogenate G6P - Sus scrofa [Reaction:R-BTA-70377] G6PD multimers dehydrogenate G6P - Bos taurus [Reaction:R-CFA-70377] G6PD multimers dehydrogenate G6P - Canis familiaris [Reaction:R-RNO-70377] G6PD multimers dehydrogenate G6P - Rattus norvegicus [Reaction:R-MMU-70377] G6PD multimers dehydrogenate G6P - Mus musculus
output	[SimpleEntity:R-ALL-31467] D-Glucono-1,5-lactone 6-phosphate [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-HSA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Homo sapiens [Reaction:R-HSA-70475] GPI dimer isomerizes Fru(6)P to G6P - Homo sapiens
releaseDate	2003-09-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70377
summation	[Summation:178460] Cytosolic glucose-6-phosphate dehydrogenase (G6PD) catalyzes...
updateTrackers	[UpdateTracker:9783579] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v56:[addLiteratureReference, modifyText] [UpdateTracker:9785077] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v52:[modifyText] [UpdateTracker:9791240] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792286] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9783579] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v56:[addLiteratureReference, modifyText] [UpdateTracker:9785077] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v52:[modifyText] [UpdateTracker:9791240] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792286] Update Tracker - [Reaction:70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - v22:[addLiteratureReference]
(replacementInstances)	[Deleted:464978] Deletion of instance: 71293
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-HSA-71336] Pentose phosphate pathway
(precedingEvent)	[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ [Reaction:R-HSA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

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