Reactome | SESN1,2,3 bind AMPK

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SESN1,2,3 bind AMPK Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5631938] Orlic-Milacic, Marija, 2014-10-27
dbId	5631941
displayName	SESN1,2,3 bind AMPK
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
input	[Complex:R-HSA-380931] p-AMPK heterotrimer:AMP [cytosol] [CandidateSet:R-HSA-5629191] SESN1,2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5631940] p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling [LiteratureReference:5632356] p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage [LiteratureReference:8855995] Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SESN1,2,3 bind AMPK
orthologousEvent	[Reaction:R-DRE-5631941] SESN1,2,3 bind AMPK - Danio rerio [Reaction:R-DDI-5631941] SESN1,2,3 bind AMPK - Dictyostelium discoideum [Reaction:R-CEL-5631941] SESN1,2,3 bind AMPK - Caenorhabditis elegans [Reaction:R-DME-5631941] SESN1,2,3 bind AMPK - Drosophila melanogaster [Reaction:R-GGA-5631941] SESN1,2,3 bind AMPK - Gallus gallus [Reaction:R-SSC-5631941] SESN1,2,3 bind AMPK - Sus scrofa [Reaction:R-BTA-5631941] SESN1,2,3 bind AMPK - Bos taurus [Reaction:R-CFA-5631941] SESN1,2,3 bind AMPK - Canis familiaris [Reaction:R-RNO-5631941] SESN1,2,3 bind AMPK - Rattus norvegicus [Reaction:R-MMU-5631941] SESN1,2,3 bind AMPK - Mus musculus
output	[Complex:R-HSA-5631939] SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5629189] TP53 stimulates expression of SESN1,2,3 genes - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5631941
summation	[Summation:5632350] SESN1, SESN2 and possibly SESN3 are able to bind the AMPK co...
updateTrackers	[UpdateTracker:9783405] Update Tracker - [Reaction:5631941] SESN1,2,3 bind AMPK - v56:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783405] Update Tracker - [Reaction:5631941] SESN1,2,3 bind AMPK - v56:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes

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