Reactome | PTEN mRNA translation negatively regulated by microRNAs

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PTEN mRNA translation negatively regulated by microRNAs Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2321907] Orlic-Milacic, M, 2012-06-18
dbId	2321904
displayName	PTEN mRNA translation negatively regulated by microRNAs
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2318746] PTEN mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2318761] The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTEN mRNA translation negatively regulated by microRNAs
output	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]
precedingEvent	[Reaction:R-HSA-2318752] miR-26A microRNAs bind PTEN mRNA - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-2321906] Negative gene expression regulation by 'PTEN mRNA:miR-26A RISC [cytosol]'
regulationReference	[RegulationReference:9641225] Negative gene expression regulation by 'PTEN mRNA:miR-26A RISC [cytosol]' The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2321904
summation	[Summation:2321901] PTEN protein synthesis is negatively regulated by microRNAs ...
updateTrackers	[UpdateTracker:9782412] Update Tracker - [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs - v59:[add_removeOutput, modifyText] [UpdateTracker:9784008] Update Tracker - [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs - v55:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782412] Update Tracker - [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs - v59:[add_removeOutput, modifyText] [UpdateTracker:9784008] Update Tracker - [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs - v55:[modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3

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