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Schema
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Reaction
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Entries
glutamine + H2O => glutamate + NH4+ [GLS]
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authored
[InstanceEdit:5674609] D'Eustachio, Peter, 2003-05-04
catalystActivity
[CatalystActivity:70608] glutaminase activity of GLS dimers [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
crossReference
[DatabaseIdentifier:11880338] Rhea:15890
dbId
70609
displayName
glutamine + H2O => glutamate + NH4+ [GLS]
edited
[InstanceEdit:660242] D'Eustachio, P, 2010-04-30
eventOf
[Pathway:R-HSA-210500] Glutamate Neurotransmitter Release Cycle - Homo sapiens
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-212658] Tranport of L-Glutamate (mitochondrial matrix) to cytosol - Homo sapiens
[Reaction:R-HSA-210444] L-Glutamate loading of synaptic vesicle - Homo sapiens
input
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113522] L-Gln [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199745] Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing
[LiteratureReference:199775] Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase
[LiteratureReference:507855] Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
glutamine + H2O => glutamate + NH4+ [GLS]
orthologousEvent
[Reaction:R-SSC-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Sus scrofa
[Reaction:R-CEL-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Caenorhabditis elegans
[Reaction:R-DME-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Drosophila melanogaster
[Reaction:R-GGA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Gallus gallus
[Reaction:R-XTR-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Xenopus tropicalis
[Reaction:R-DRE-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Danio rerio
[Reaction:R-BTA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Bos taurus
[Reaction:R-CFA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Canis familiaris
[Reaction:R-RNO-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Rattus norvegicus
[Reaction:R-MMU-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Mus musculus
output
[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
[SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
precedingEvent
[BlackBoxEvent:R-HSA-212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix - Homo sapiens
[Reaction:R-HSA-212614] Glutamine transport from astrocytes - Homo sapiens
[BlackBoxEvent:R-HSA-5632924] TP53 stimulates GLS2 transcription - Homo sapiens
releaseDate
2003-05-04
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70609
summation
[Summation:178812] Mitochondrial glutaminase (GLS) catalyzes the hydrolysis of ...
Referrals
(hasEvent)
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
[Pathway:R-HSA-210500] Glutamate Neurotransmitter Release Cycle
(precedingEvent)
[BlackBoxEvent:R-HSA-212658] Tranport of L-Glutamate (mitochondrial matrix) to cytosol
[Reaction:R-HSA-210444] L-Glutamate loading of synaptic vesicle
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