Reactome | glutamine + H2O => glutamate + NH4+ [GLS]

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glutamine + H2O => glutamate + NH4+ [GLS] Show undefined attributes

authored	[InstanceEdit:5674609] D'Eustachio, Peter, 2003-05-04
catalystActivity	[CatalystActivity:70608] glutaminase activity of GLS dimers [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:11880338] Rhea:15890
dbId	70609
displayName	glutamine + H2O => glutamate + NH4+ [GLS]
edited	[InstanceEdit:660242] D'Eustachio, P, 2010-04-30
eventOf	[Pathway:R-HSA-210500] Glutamate Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-212658] Tranport of L-Glutamate (mitochondrial matrix) to cytosol - Homo sapiens [Reaction:R-HSA-210444] L-Glutamate loading of synaptic vesicle - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113522] L-Gln [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199745] Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing [LiteratureReference:199775] Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase [LiteratureReference:507855] Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	glutamine + H2O => glutamate + NH4+ [GLS]
orthologousEvent	[Reaction:R-SSC-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Sus scrofa [Reaction:R-CEL-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Caenorhabditis elegans [Reaction:R-DME-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Drosophila melanogaster [Reaction:R-GGA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Gallus gallus [Reaction:R-XTR-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Xenopus tropicalis [Reaction:R-DRE-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Danio rerio [Reaction:R-BTA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Bos taurus [Reaction:R-CFA-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Canis familiaris [Reaction:R-RNO-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Rattus norvegicus [Reaction:R-MMU-70609] glutamine + H2O => glutamate + NH4+ [GLS] - Mus musculus
output	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-212614] Glutamine transport from astrocytes - Homo sapiens [BlackBoxEvent:R-HSA-5632924] TP53 stimulates GLS2 transcription - Homo sapiens
releaseDate	2003-05-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70609
summation	[Summation:178812] Mitochondrial glutaminase (GLS) catalyzes the hydrolysis of ...

Referrals

(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-HSA-210500] Glutamate Neurotransmitter Release Cycle
(precedingEvent)	[BlackBoxEvent:R-HSA-212658] Tranport of L-Glutamate (mitochondrial matrix) to cytosol [Reaction:R-HSA-210444] L-Glutamate loading of synaptic vesicle

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