Reactome | PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

Schema > Reaction > Entries

PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O Show undefined attributes

authored	[InstanceEdit:3323054] May, B, 2013-05-05
catalystActivity	[CatalystActivity:3341280] thioredoxin peroxidase activity of PRDX1,2,5 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643451] thioredoxin peroxidase activity of PRDX1,2,5 [cytosol] Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3341366] May, B, 2013-05-11
dbId	3341343
displayName	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
edited	[InstanceEdit:3323054] May, B, 2013-05-05
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens [Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent	[Reaction:R-HSA-5631885] PRDX1 overoxidizes - Homo sapiens
input	[SimpleEntity:R-ALL-29408] H2O2 [cytosol] [EntityWithAccessionedSequence:R-HSA-66000] TXN [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3323082] Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study [LiteratureReference:3341330] Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2 [LiteratureReference:3341394] Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
orthologousEvent	[Reaction:R-DRE-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Danio rerio [Reaction:R-CEL-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Caenorhabditis elegans [Reaction:R-DME-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Drosophila melanogaster [Reaction:R-GGA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Gallus gallus [Reaction:R-SSC-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Sus scrofa [Reaction:R-BTA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Bos taurus [Reaction:R-CFA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Canis familiaris [Reaction:R-RNO-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Rattus norvegicus [Reaction:R-MMU-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-73668] 2xHC-TXN [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-HSA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Homo sapiens [Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3341343
summation	[Summation:3343708] Peroxiredoxin 1 (PRDX1), PRDX2, and PRDX5 in the cytosol red...

Referrals

(hasEvent)	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-5631885] PRDX1 overoxidizes