Reactome | TP53 binds the PTEN promoter

Schema > Reaction > Entries

TP53 binds the PTEN promoter Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5632945] Orlic-Milacic, Marija, 2014-10-29
dbId	5632939
displayName	TP53 binds the PTEN promoter
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5632949] PTEN gene [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5632944] Regulation of PTEN transcription by p53
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 binds the PTEN promoter
output	[Complex:R-HSA-5632941] TP53 Tetramer:PTEN Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5632939
summation	[Summation:5632996] PTEN (phosphatase and tensin homolog deleted in chromosome 1...
updateTrackers	[UpdateTracker:9783582] Update Tracker - [Reaction:5632939] TP53 binds the PTEN promoter - v56:[modifyText] [UpdateTracker:9783974] Update Tracker - [Reaction:5632939] TP53 binds the PTEN promoter - v55:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783582] Update Tracker - [Reaction:5632939] TP53 binds the PTEN promoter - v56:[modifyText] [UpdateTracker:9783974] Update Tracker - [Reaction:5632939] TP53 binds the PTEN promoter - v55:[modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN