Reactome | SESN1,2,3 bind overoxidized PRDX1

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SESN1,2,3 bind overoxidized PRDX1 Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5631901] Orlic-Milacic, Marija, 2014-10-27
dbId	5631903
displayName	SESN1,2,3 bind overoxidized PRDX1
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
input	[Complex:R-HSA-5631882] HOOS-C52-PRDX1 dimer [cytosol] [CandidateSet:R-HSA-5629191] SESN1,2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5631890] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [LiteratureReference:5631926] Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses [LiteratureReference:5631909] Role of sestrin2 in peroxide signaling in macrophages [LiteratureReference:5631923] Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins [LiteratureReference:8855982] Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SESN1,2,3 bind overoxidized PRDX1 Sestrins bind overoxidized PRDX1
orthologousEvent	[Reaction:R-DRE-5631903] SESN1,2,3 bind overoxidized PRDX1 - Danio rerio [Reaction:R-DDI-5631903] SESN1,2,3 bind overoxidized PRDX1 - Dictyostelium discoideum [Reaction:R-CEL-5631903] SESN1,2,3 bind overoxidized PRDX1 - Caenorhabditis elegans [Reaction:R-DME-5631903] SESN1,2,3 bind overoxidized PRDX1 - Drosophila melanogaster [Reaction:R-GGA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Gallus gallus [Reaction:R-XTR-5631903] SESN1,2,3 bind overoxidized PRDX1 - Xenopus tropicalis [Reaction:R-SSC-5631903] SESN1,2,3 bind overoxidized PRDX1 - Sus scrofa [Reaction:R-BTA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Bos taurus [Reaction:R-CFA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Canis familiaris [Reaction:R-RNO-5631903] SESN1,2,3 bind overoxidized PRDX1 - Rattus norvegicus [Reaction:R-MMU-5631903] SESN1,2,3 bind overoxidized PRDX1 - Mus musculus
output	[Complex:R-HSA-5631902] SESN1,2,3:HOOS-C52-PRDX1 dimer [cytosol]
precedingEvent	[Reaction:R-HSA-5631885] PRDX1 overoxidizes - Homo sapiens [BlackBoxEvent:R-HSA-5629189] TP53 stimulates expression of SESN1,2,3 genes - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5631903
summation	[Summation:5631906] Sestrins (SESN1, SESN2 and likely SESN3) bind overoxidized P...
updateTrackers	[UpdateTracker:9783665] Update Tracker - [Reaction:5631903] SESN1,2,3 bind overoxidized PRDX1 - v56:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783665] Update Tracker - [Reaction:5631903] SESN1,2,3 bind overoxidized PRDX1 - v56:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes

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