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Schema
>
Reaction
>
Entries
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
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authored
[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
catalystActivity
[CatalystActivity:71681] glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:11879888] Rhea:11742
dbId
71682
displayName
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
edited
[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
eventOf
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent
[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Homo sapiens
input
[SimpleEntity:R-ALL-111745] GSSG [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200187] Familial deficiency of glutathione reductase in human blood cells
[LiteratureReference:3779352] PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
orthologousEvent
[Reaction:R-PFA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Plasmodium falciparum
[Reaction:R-SCE-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Saccharomyces cerevisiae
[Reaction:R-SPO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Schizosaccharomyces pombe
[Reaction:R-DDI-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Dictyostelium discoideum
[Reaction:R-CEL-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Caenorhabditis elegans
[Reaction:R-GGA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Gallus gallus
[Reaction:R-XTR-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Xenopus tropicalis
[Reaction:R-SSC-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Sus scrofa
[Reaction:R-BTA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Bos taurus
[Reaction:R-CFA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Canis familiaris
[Reaction:R-RNO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Rattus norvegicus
[Reaction:R-MMU-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29450] GSH [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-71299] 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ - Homo sapiens
[Reaction:R-HSA-70377] alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - Homo sapiens
[Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Homo sapiens
[Reaction:R-HSA-198813] GSTO dimers reduce DeHA to AscH- - Homo sapiens
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-71682
summation
[Summation:499935] Cytosolic glutathione reductase catalyzes the reaction of gl...
Referrals
(hasEvent)
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)
[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
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