Reactome | glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Schema > Reaction > Entries

glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ Show undefined attributes

authored	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
catalystActivity	[CatalystActivity:71681] glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667682] RHEA:11742 [DatabaseIdentifier:9975904] RHEA:11742
dbId	71682
displayName	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
edited	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens [Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens [Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent	[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Homo sapiens
input	[SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200187] Familial deficiency of glutathione reductase in human blood cells [LiteratureReference:3779352] PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ glutathione disulfide + NADPH + H(+) => 2 glutathione + NADP(+)
orthologousEvent	[Reaction:R-DRE-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Danio rerio [Reaction:R-SCE-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Saccharomyces cerevisiae [Reaction:R-SPO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Schizosaccharomyces pombe [Reaction:R-DDI-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Dictyostelium discoideum [Reaction:R-CEL-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Caenorhabditis elegans [Reaction:R-GGA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Gallus gallus [Reaction:R-XTR-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Xenopus tropicalis [Reaction:R-SSC-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Sus scrofa [Reaction:R-BTA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Bos taurus [Reaction:R-CFA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Canis familiaris [Reaction:R-RNO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Rattus norvegicus [Reaction:R-MMU-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Mus musculus
output	2 × [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-71299] PGD decarboxylates 6-phospho-D-gluconate - Homo sapiens [Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P - Homo sapiens [Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Homo sapiens [Reaction:R-HSA-198813] GSTO dimers reduce DeHA to AscH- - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71682
summation	[Summation:499935] Cytosolic glutathione reductase catalyzes the reaction of gl...
updateTrackers	[UpdateTracker:9792257] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v22:[addLiteratureReference] [UpdateTracker:9787201] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v46:[addLiteratureReference, modifyText] [UpdateTracker:9791058] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v32:[add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9792257] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v22:[addLiteratureReference] [UpdateTracker:9787201] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v46:[addLiteratureReference, modifyText] [UpdateTracker:9791058] Update Tracker - [Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - v32:[add_removeSummation]
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates [Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

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