Reactome | TP53 stimulates transcription of RRM2B gene

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TP53 stimulates transcription of RRM2B gene Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5632891] Orlic-Milacic, Marija, 2014-10-29
dbId	5632892
displayName	TP53 stimulates transcription of RRM2B gene
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens [Reaction:R-HSA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5632883] RRM2B Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:5632908] Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion [LiteratureReference:5632896] p53 regulates mtDNA copy number and mitocheckpoint pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates transcription of RRM2B gene
output	[EntityWithAccessionedSequence:R-HSA-111792] RRM2B [cytosol]
precedingEvent	[Reaction:R-HSA-5632887] TP53 binds the RRM2B gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5632893] Positive gene expression regulation by 'TP53 Tetramer:RRM2B Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642131] Positive gene expression regulation by 'TP53 Tetramer:RRM2B Gene [nucleoplasm]' A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5632892
summation	[Summation:5632900] TP53 (p53) directly stimulates transcription of RRM2B gene (...
updateTrackers	[UpdateTracker:9783919] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v55:[modifyText] [UpdateTracker:9783587] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783919] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v55:[modifyText] [UpdateTracker:9783587] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v56:[modifyText]
(precedingEvent)	[Reaction:R-HSA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) [Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes