Reactome | TP53 Regulates Metabolic Genes

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TP53 Regulates Metabolic Genes Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910638
displayName	TP53 Regulates Metabolic Genes
eventOf	[Pathway:R-DME-3700989] Transcriptional Regulation by TP53 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-70475] GPI dimer isomerizes Fru(6)P to G6P - Drosophila melanogaster [Reaction:R-DME-70377] G6PD multimers dehydrogenate G6P - Drosophila melanogaster [Reaction:R-DME-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Drosophila melanogaster [Reaction:R-DME-73646] Regeneration of active (reduced) Thioredoxin - Drosophila melanogaster [Reaction:R-DME-5631885] PRDX1 overoxidizes - Drosophila melanogaster [Reaction:R-DME-5631903] SESN1,2,3 bind overoxidized PRDX1 - Drosophila melanogaster [Reaction:R-DME-380927] p-AMPK phosphorylates TSC1:TSC2 - Drosophila melanogaster [Reaction:R-DME-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Drosophila melanogaster [Reaction:R-DME-5631941] SESN1,2,3 bind AMPK - Drosophila melanogaster [Reaction:R-DME-165179] Formation of TSC1:TSC2 complex - Drosophila melanogaster [Reaction:R-DME-198609] AKT phosphorylates TSC2, inhibiting it - Drosophila melanogaster [Reaction:R-DME-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Drosophila melanogaster [Reaction:R-DME-5632738] DDIT4 binds 14-3-3 dimer - Drosophila melanogaster [Reaction:R-DME-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Drosophila melanogaster [Reaction:R-DME-70609] glutamine + H2O => glutamate + NH4+ (GLS) - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TP53 Regulates Metabolic Genes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5628897
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)	[Pathway:R-DME-9864848] Complex IV assembly
(inferredTo)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes

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