Reactome | TP53 stimulates GLS2 transcription

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TP53 stimulates GLS2 transcription Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	omitted
compartment	[Compartment:5460] mitochondrial matrix [Compartment:7660] nucleoplasm
created	[InstanceEdit:5632918] Orlic-Milacic, Marija, 2014-10-29
dbId	5632924
displayName	TP53 stimulates GLS2 transcription
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-70609] glutamine + H2O => glutamate + NH4+ (GLS) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5632920] GLS2 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5632922] Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function [LiteratureReference:8856017] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates GLS2 transcription
output	[Complex:R-HSA-507858] GLS2 dimer [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-5632914] TP53 binds the GLS2 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5632932] Positive gene expression regulation by 'TP53 Tetramer:GLS2 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641244] Positive gene expression regulation by 'TP53 Tetramer:GLS2 Gene [nucleoplasm]' Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5632924
summation	[Summation:5632913] TP53 (p53) directly stimulates transcription of mitochondria...
updateTrackers	[UpdateTracker:9783749] Update Tracker - [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription - v56:[addLiteratureReference, modifyText] [UpdateTracker:9783800] Update Tracker - [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription - v55:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783749] Update Tracker - [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription - v56:[addLiteratureReference, modifyText] [UpdateTracker:9783800] Update Tracker - [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription - v55:[modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-70609] glutamine + H2O => glutamate + NH4+ (GLS)