Reactome | TP53 stimulates expression of SESN1,2,3 genes

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TP53 stimulates expression of SESN1,2,3 genes Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5629190] Orlic-Milacic, Marija, 2014-10-24
dbId	5629189
displayName	TP53 stimulates expression of SESN1,2,3 genes
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-5631941] SESN1,2,3 bind AMPK - Homo sapiens [Reaction:R-HSA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Homo sapiens
input	[CandidateSet:R-HSA-5629150] SESN1,2,3 Genes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5629163] PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes [LiteratureReference:5629169] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [LiteratureReference:5629185] NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation [LiteratureReference:8855971] p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates expression of SESN1,2,3 genes
output	[CandidateSet:R-HSA-5629191] SESN1,2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-5629187] TP53 binds regulatory elements of SESN1,2,3 genes - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5629192] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]'
regulationReference	[RegulationReference:9641838] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]' PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5629189
summation	[Summation:5629194] Sestrins (SESN) are a small family of stress-sensitive gene ...
updateTrackers	[UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-5631903] SESN1,2,3 bind overoxidized PRDX1 [Reaction:R-HSA-5631941] SESN1,2,3 bind AMPK