Reactome | TP53 stimulates TIGAR expression

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TP53 stimulates TIGAR expression Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:5628895] Orlic-Milacic, Marija, 2014-10-24
dbId	5628901
displayName	TP53 stimulates TIGAR expression
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5628852] TIGAR Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5628862] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:8855796] TIGAR, TIGAR, burning bright [LiteratureReference:8855803] Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates TIGAR expression
output	[EntityWithAccessionedSequence:R-HSA-5628829] TIGAR [cytosol]
precedingEvent	[Reaction:R-HSA-5628899] TP53 binds the TIGAR gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5628903] Positive gene expression regulation by 'TP53 Tetramer:TIGAR Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642556] Positive gene expression regulation by 'TP53 Tetramer:TIGAR Gene [nucleoplasm]' TIGAR, a p53-inducible regulator of glycolysis and apoptosis
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5628901
summation	[Summation:5628896] TIGAR was first identified as a TP53 target through high-thr...
updateTrackers	[UpdateTracker:9783452] Update Tracker - [BlackBoxEvent:5628901] TP53 stimulates TIGAR expression - v56:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783452] Update Tracker - [BlackBoxEvent:5628901] TP53 stimulates TIGAR expression - v56:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate