Reactome | Formation of TSC1:TSC2 complex

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Formation of TSC1:TSC2 complex Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:165173] de Bono, B, 2005-08-02 14:40:35
dbId	165179
displayName	Formation of TSC1:TSC2 complex
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-165169] TSC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2980548] TSC2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5632718] Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning [LiteratureReference:165178] Signaling pathways: the benefits of good communication
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Formation of TSC1:TSC2 complex
orthologousEvent	[Reaction:R-SPO-165179] Formation of TSC1:TSC2 complex - Schizosaccharomyces pombe [Reaction:R-DME-165179] Formation of TSC1:TSC2 complex - Drosophila melanogaster [Reaction:R-GGA-165179] Formation of TSC1:TSC2 complex - Gallus gallus [Reaction:R-XTR-165179] Formation of TSC1:TSC2 complex - Xenopus tropicalis [Reaction:R-SSC-165179] Formation of TSC1:TSC2 complex - Sus scrofa [Reaction:R-BTA-165179] Formation of TSC1:TSC2 complex - Bos taurus [Reaction:R-CFA-165179] Formation of TSC1:TSC2 complex - Canis familiaris [Reaction:R-RNO-165179] Formation of TSC1:TSC2 complex - Rattus norvegicus [Reaction:R-MMU-165179] Formation of TSC1:TSC2 complex - Mus musculus
output	[Complex:R-HSA-165175] TSC1:TSC2 [cytosol]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-165179
summation	[Summation:178794] A membrane-associated TSC1 (hamartin) binds TSC2 (tuberin) a...

Referrals

(hasEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)	[Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2