Reactome | PYR [cytosol]

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PYR [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-GGA-372910] pyruvate + NADH + H+ <=> lactate + NAD+ - Gallus gallus [Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens [Reaction:R-PFA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Plasmodium falciparum [Reaction:R-SCE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Saccharomyces cerevisiae [Reaction:R-SPO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Schizosaccharomyces pombe [Reaction:R-DDI-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Dictyostelium discoideum [Reaction:R-CEL-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Caenorhabditis elegans [Reaction:R-DME-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Drosophila melanogaster [Reaction:R-GGA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Gallus gallus [Reaction:R-XTR-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Xenopus tropicalis [Reaction:R-DRE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Danio rerio [Reaction:R-SSC-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Sus scrofa [Reaction:R-BTA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Bos taurus [Reaction:R-CFA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Canis familiaris [Reaction:R-RNO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Rattus norvegicus [Reaction:R-MMU-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Mus musculus [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens [Reaction:R-CEL-71849] LDH tetramer reduces PYR to LACT - Caenorhabditis elegans [Reaction:R-DME-71849] LDH tetramer reduces PYR to LACT - Drosophila melanogaster [Reaction:R-GGA-71849] LDH tetramer reduces PYR to LACT - Gallus gallus [Reaction:R-XTR-71849] LDH tetramer reduces PYR to LACT - Xenopus tropicalis [Reaction:R-DRE-71849] LDH tetramer reduces PYR to LACT - Danio rerio [Reaction:R-SSC-71849] LDH tetramer reduces PYR to LACT - Sus scrofa [Reaction:R-BTA-71849] LDH tetramer reduces PYR to LACT - Bos taurus [Reaction:R-CFA-71849] LDH tetramer reduces PYR to LACT - Canis familiaris [Reaction:R-RNO-71849] LDH tetramer reduces PYR to LACT - Rattus norvegicus [Reaction:R-MMU-71849] LDH tetramer reduces PYR to LACT - Mus musculus [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens [Reaction:R-HSA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Homo sapiens [Reaction:R-MMU-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Mus musculus [Reaction:R-RNO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Rattus norvegicus [Reaction:R-CFA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Canis familiaris [Reaction:R-BTA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Bos taurus [Reaction:R-SSC-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Sus scrofa [Reaction:R-DRE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Danio rerio [Reaction:R-XTR-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Xenopus tropicalis [Reaction:R-DME-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Drosophila melanogaster [Reaction:R-CEL-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Caenorhabditis elegans [Reaction:R-DDI-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Dictyostelium discoideum [Reaction:R-SPO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Schizosaccharomyces pombe [Reaction:R-SCE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Saccharomyces cerevisiae [Reaction:R-GGA-372359] pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] - Gallus gallus [Reaction:R-SCE-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Saccharomyces cerevisiae [Reaction:R-SPO-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Schizosaccharomyces pombe [Reaction:R-DDI-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Dictyostelium discoideum [Reaction:R-CEL-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Caenorhabditis elegans [Reaction:R-DME-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Drosophila melanogaster [Reaction:R-GGA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Gallus gallus [Reaction:R-XTR-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Xenopus tropicalis [Reaction:R-DRE-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Danio rerio [Reaction:R-SSC-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Sus scrofa [Reaction:R-CFA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Canis familiaris [Reaction:R-RNO-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Rattus norvegicus [Reaction:R-MMU-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Mus musculus [Reaction:R-HSA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Homo sapiens [Reaction:R-BTA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Bos taurus [Reaction:R-SCE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Saccharomyces cerevisiae [Reaction:R-SPO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Schizosaccharomyces pombe [Reaction:R-DDI-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Dictyostelium discoideum [Reaction:R-CEL-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Caenorhabditis elegans [Reaction:R-DME-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Drosophila melanogaster [Reaction:R-GGA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Gallus gallus [Reaction:R-XTR-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Xenopus tropicalis [Reaction:R-DRE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Danio rerio [Reaction:R-SSC-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Sus scrofa [Reaction:R-BTA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Bos taurus [Reaction:R-CFA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Canis familiaris [Reaction:R-MMU-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Mus musculus [Reaction:R-HSA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Homo sapiens [Reaction:R-RNO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Rattus norvegicus [Reaction:R-RNO-372347] Cytosolic PYR is transported to the mitochondrial matrix - Rattus norvegicus
crossReference	[DatabaseIdentifier:29399] COMPOUND:C00022
dbId	29398
deleted	[Deleted:9930586] Deletion of instance: 5357717
displayName	PYR [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-8876304] LACT, PYR, NCA [cytosol] [DefinedSet:R-ALL-433686] MCT substrates [cytosol] [DefinedSet:R-ALL-429748] monocarboxylates transported by SLC5A8 [cytosol]
modified	[InstanceEdit:9674772] D'Eustachio, Peter, 2020-01-23
name	PYR Pyruvate pyruvic acid 2-Oxopropanoate 2-Oxopropanoic acid Pyroracemic acid
producedByEvent	[Reaction:R-GGA-372903] lactate + NAD+ <=> pyruvate + NADH + H+ - Gallus gallus [Reaction:R-GGA-353056] phosphoenolpyruvate + ADP => pyruvate + ATP - Gallus gallus [Reaction:R-SCE-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Saccharomyces cerevisiae [Reaction:R-SPO-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Schizosaccharomyces pombe [Reaction:R-DDI-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Dictyostelium discoideum [Reaction:R-CEL-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Caenorhabditis elegans [Reaction:R-GGA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Gallus gallus [Reaction:R-XTR-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Xenopus tropicalis [Reaction:R-SSC-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Sus scrofa [Reaction:R-BTA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Bos taurus [Reaction:R-CFA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Canis familiaris [Reaction:R-RNO-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Rattus norvegicus [Reaction:R-MMU-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Mus musculus [Reaction:R-HSA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Homo sapiens [Reaction:R-SCE-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Saccharomyces cerevisiae [Reaction:R-SPO-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Schizosaccharomyces pombe [Reaction:R-DDI-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Dictyostelium discoideum [Reaction:R-CEL-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Caenorhabditis elegans [Reaction:R-GGA-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Gallus gallus [Reaction:R-XTR-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Xenopus tropicalis [Reaction:R-SSC-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Sus scrofa [Reaction:R-BTA-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Bos taurus [Reaction:R-CFA-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Canis familiaris [Reaction:R-RNO-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Rattus norvegicus [Reaction:R-MMU-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Mus musculus [Reaction:R-HSA-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Homo sapiens [Reaction:R-CEL-70510] LDH tetramer oxidises LACT to PYR - Caenorhabditis elegans [Reaction:R-DME-70510] LDH tetramer oxidises LACT to PYR - Drosophila melanogaster [Reaction:R-GGA-70510] LDH tetramer oxidises LACT to PYR - Gallus gallus [Reaction:R-XTR-70510] LDH tetramer oxidises LACT to PYR - Xenopus tropicalis [Reaction:R-DRE-70510] LDH tetramer oxidises LACT to PYR - Danio rerio [Reaction:R-SSC-70510] LDH tetramer oxidises LACT to PYR - Sus scrofa [Reaction:R-BTA-70510] LDH tetramer oxidises LACT to PYR - Bos taurus [Reaction:R-CFA-70510] LDH tetramer oxidises LACT to PYR - Canis familiaris [Reaction:R-RNO-70510] LDH tetramer oxidises LACT to PYR - Rattus norvegicus [Reaction:R-MMU-70510] LDH tetramer oxidises LACT to PYR - Mus musculus [Reaction:R-HSA-70510] LDH tetramer oxidises LACT to PYR - Homo sapiens [Reaction:R-CEL-9012036] ME1 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-DME-9012036] ME1 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-GGA-9012036] ME1 tetramer decarboxylates MAL to PYR - Gallus gallus [Reaction:R-DRE-9012036] ME1 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-SSC-9012036] ME1 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-BTA-9012036] ME1 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-CFA-9012036] ME1 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-RNO-9012036] ME1 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-MMU-9012036] ME1 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-HSA-9012036] ME1 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-CEL-9861660] ME1 tetramer decarboxylates OA to PYR - Caenorhabditis elegans [Reaction:R-DME-9861660] ME1 tetramer decarboxylates OA to PYR - Drosophila melanogaster [Reaction:R-GGA-9861660] ME1 tetramer decarboxylates OA to PYR - Gallus gallus [Reaction:R-DRE-9861660] ME1 tetramer decarboxylates OA to PYR - Danio rerio [Reaction:R-SSC-9861660] ME1 tetramer decarboxylates OA to PYR - Sus scrofa [Reaction:R-BTA-9861660] ME1 tetramer decarboxylates OA to PYR - Bos taurus [Reaction:R-CFA-9861660] ME1 tetramer decarboxylates OA to PYR - Canis familiaris [Reaction:R-RNO-9861660] ME1 tetramer decarboxylates OA to PYR - Rattus norvegicus [Reaction:R-MMU-9861660] ME1 tetramer decarboxylates OA to PYR - Mus musculus [Reaction:R-HSA-9861660] ME1 tetramer decarboxylates OA to PYR - Homo sapiens [Reaction:R-SCE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Saccharomyces cerevisiae [Reaction:R-SPO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Schizosaccharomyces pombe [Reaction:R-DDI-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Dictyostelium discoideum [Reaction:R-CEL-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Caenorhabditis elegans [Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Homo sapiens [Reaction:R-MMU-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Mus musculus [Reaction:R-RNO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Rattus norvegicus [Reaction:R-CFA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Canis familiaris [Reaction:R-BTA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Bos taurus [Reaction:R-SSC-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Sus scrofa [Reaction:R-DRE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Danio rerio [Reaction:R-XTR-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Xenopus tropicalis [Reaction:R-DME-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Drosophila melanogaster [Reaction:R-HSA-2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH - Homo sapiens [Reaction:R-SCE-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Saccharomyces cerevisiae [Reaction:R-DDI-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Dictyostelium discoideum [Reaction:R-GGA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Gallus gallus [Reaction:R-XTR-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Xenopus tropicalis [Reaction:R-SSC-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Sus scrofa [Reaction:R-BTA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Bos taurus [Reaction:R-CFA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Canis familiaris [Reaction:R-RNO-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Rattus norvegicus [Reaction:R-MMU-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Mus musculus [Reaction:R-HSA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Homo sapiens [Reaction:R-DRE-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ - Danio rerio [Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Homo sapiens [Reaction:R-MMU-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Mus musculus [Reaction:R-RNO-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Rattus norvegicus [Reaction:R-CFA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Canis familiaris [Reaction:R-BTA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Bos taurus [Reaction:R-SSC-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Sus scrofa [Reaction:R-DRE-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Danio rerio [Reaction:R-XTR-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Xenopus tropicalis [Reaction:R-GGA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Gallus gallus [Reaction:R-HSA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Homo sapiens [Reaction:R-MMU-71670] Pyruvate kinase dephosphorylates PEP to PYR - Mus musculus [Reaction:R-RNO-71670] Pyruvate kinase dephosphorylates PEP to PYR - Rattus norvegicus [Reaction:R-CFA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Canis familiaris [Reaction:R-BTA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Bos taurus [Reaction:R-SSC-71670] Pyruvate kinase dephosphorylates PEP to PYR - Sus scrofa [Reaction:R-DRE-71670] Pyruvate kinase dephosphorylates PEP to PYR - Danio rerio [Reaction:R-XTR-71670] Pyruvate kinase dephosphorylates PEP to PYR - Xenopus tropicalis [Reaction:R-GGA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Gallus gallus [Reaction:R-DME-71670] Pyruvate kinase dephosphorylates PEP to PYR - Drosophila melanogaster [Reaction:R-CEL-71670] Pyruvate kinase dephosphorylates PEP to PYR - Caenorhabditis elegans [Reaction:R-DDI-71670] Pyruvate kinase dephosphorylates PEP to PYR - Dictyostelium discoideum [Reaction:R-SPO-71670] Pyruvate kinase dephosphorylates PEP to PYR - Schizosaccharomyces pombe [Reaction:R-SCE-71670] Pyruvate kinase dephosphorylates PEP to PYR - Saccharomyces cerevisiae [Reaction:R-PFA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Plasmodium falciparum [Reaction:R-RNO-2408538] MeSec is hydrolysed to MeSeH by PXLP-K211-Cth - Rattus norvegicus [Reaction:R-SCE-1614614] Cysteine is degraded to pyruvate and H2S - Saccharomyces cerevisiae [Reaction:R-SPO-1614614] Cysteine is degraded to pyruvate and H2S - Schizosaccharomyces pombe [Reaction:R-DDI-1614614] Cysteine is degraded to pyruvate and H2S - Dictyostelium discoideum [Reaction:R-CEL-1614614] Cysteine is degraded to pyruvate and H2S - Caenorhabditis elegans [Reaction:R-DME-1614614] Cysteine is degraded to pyruvate and H2S - Drosophila melanogaster [Reaction:R-GGA-1614614] Cysteine is degraded to pyruvate and H2S - Gallus gallus [Reaction:R-XTR-1614614] Cysteine is degraded to pyruvate and H2S - Xenopus tropicalis [Reaction:R-DRE-1614614] Cysteine is degraded to pyruvate and H2S - Danio rerio [Reaction:R-SSC-1614614] Cysteine is degraded to pyruvate and H2S - Sus scrofa [Reaction:R-BTA-1614614] Cysteine is degraded to pyruvate and H2S - Bos taurus [Reaction:R-CFA-1614614] Cysteine is degraded to pyruvate and H2S - Canis familiaris [Reaction:R-RNO-1614614] Cysteine is degraded to pyruvate and H2S - Rattus norvegicus [Reaction:R-MMU-1614614] Cysteine is degraded to pyruvate and H2S - Mus musculus [Reaction:R-HSA-1614614] Cysteine is degraded to pyruvate and H2S - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:15361] pyruvate [ChEBI:15361]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29398
updateTrackers	[UpdateTracker:9889784] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v52:[modifyName] [UpdateTracker:9901146] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v72:[add_removeReferenceEntity] [UpdateTracker:9874479] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v43:[addName]

Referrals

(input)	[Reaction:R-GGA-372359] pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] [Reaction:R-GGA-372910] pyruvate + NADH + H+ <=> lactate + NAD+ [Reaction:R-SCE-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-SPO-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-DDI-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-CEL-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-DME-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-GGA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-XTR-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-DRE-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-SSC-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-CFA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-RNO-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-MMU-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-HSA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-BTA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-SCE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-SPO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DDI-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-CEL-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DME-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-GGA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-XTR-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DRE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-SSC-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-BTA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-CFA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-MMU-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-HSA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-RNO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-RNO-372347] Cytosolic PYR is transported to the mitochondrial matrix [Reaction:R-PFA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-SCE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-SPO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-DDI-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-CEL-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-DME-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-GGA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-XTR-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-DRE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-SSC-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-BTA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-CFA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-RNO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-MMU-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-CEL-71849] LDH tetramer reduces PYR to LACT [Reaction:R-DME-71849] LDH tetramer reduces PYR to LACT [Reaction:R-GGA-71849] LDH tetramer reduces PYR to LACT [Reaction:R-XTR-71849] LDH tetramer reduces PYR to LACT [Reaction:R-DRE-71849] LDH tetramer reduces PYR to LACT [Reaction:R-SSC-71849] LDH tetramer reduces PYR to LACT [Reaction:R-BTA-71849] LDH tetramer reduces PYR to LACT [Reaction:R-CFA-71849] LDH tetramer reduces PYR to LACT [Reaction:R-RNO-71849] LDH tetramer reduces PYR to LACT [Reaction:R-MMU-71849] LDH tetramer reduces PYR to LACT [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT [Reaction:R-HSA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-MMU-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-RNO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-CFA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-BTA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-SSC-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-DRE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-XTR-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-DME-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-CEL-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-DDI-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-SPO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Reaction:R-SCE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala
(output)	[Reaction:R-GGA-372903] lactate + NAD+ <=> pyruvate + NADH + H+ [Reaction:R-GGA-353056] phosphoenolpyruvate + ADP => pyruvate + ATP [Reaction:R-RNO-2408538] MeSec is hydrolysed to MeSeH by PXLP-K211-Cth [Reaction:R-HSA-2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH [Reaction:R-SCE-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-SPO-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-DDI-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-CEL-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-GGA-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-XTR-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-SSC-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-BTA-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-CFA-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-RNO-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-MMU-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-HSA-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-SCE-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-SPO-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-DDI-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-CEL-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-GGA-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-XTR-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-SSC-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-BTA-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-CFA-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-RNO-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-MMU-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-HSA-9034539] PXLP-K56-SRR dimer deaminates L-Ser [Reaction:R-SCE-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-DDI-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-GGA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-XTR-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-SSC-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-BTA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-CFA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-RNO-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-MMU-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-HSA-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-DRE-9929460] SDS dimers:PXLP convert L-Ser to PYR and NH4+ [Reaction:R-CEL-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-DME-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-GGA-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-XTR-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-DRE-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-SSC-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-BTA-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-CFA-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-RNO-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-MMU-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-HSA-70510] LDH tetramer oxidises LACT to PYR [Reaction:R-CEL-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-DME-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-GGA-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-DRE-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-SSC-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-BTA-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-CFA-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-RNO-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-SCE-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-SPO-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-DDI-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-CEL-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-DME-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-GGA-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-XTR-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-DRE-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-SSC-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-BTA-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-CFA-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-RNO-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-MMU-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-HSA-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-MMU-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-CEL-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-DME-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-GGA-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-DRE-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-SSC-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-BTA-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-CFA-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-RNO-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-MMU-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-HSA-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-SCE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-SPO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-DDI-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-CEL-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-MMU-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-RNO-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-CFA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-BTA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-SSC-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-DRE-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-XTR-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-GGA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Reaction:R-HSA-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-MMU-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-RNO-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-CFA-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-BTA-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-SSC-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-DRE-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-XTR-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-GGA-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-DME-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-CEL-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-DDI-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-SPO-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-SCE-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-PFA-71670] Pyruvate kinase dephosphorylates PEP to PYR [Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-MMU-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-RNO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-CFA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-BTA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-SSC-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-DRE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-XTR-70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Reaction:R-DME-70523] PXLP-K314-GPT transaminates L-Ala to form PYR
(hasMember)	[DefinedSet:R-ALL-8876304] LACT, PYR, NCA [cytosol] [DefinedSet:R-ALL-429748] monocarboxylates transported by SLC5A8 [cytosol] [DefinedSet:R-ALL-433686] MCT substrates [cytosol]
(replacementInstances)	[Deleted:9930586] Deletion of instance: 5357717
(updatedInstance)	[UpdateTracker:9889784] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v52:[modifyName] [UpdateTracker:9901146] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v72:[add_removeReferenceEntity] [UpdateTracker:9874479] Update Tracker - [SimpleEntity:29398] PYR [cytosol] - v43:[addName]

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