Reactome | PXLP-K314-GPT transaminates PYR to form L-Ala

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PXLP-K314-GPT transaminates PYR to form L-Ala Show undefined attributes

catalystActivity	[CatalystActivity:70522] L-alanine:2-oxoglutarate aminotransferase activity of PXLP-K314-GPT dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643950] L-alanine:2-oxoglutarate aminotransferase activity of GPT dimer [cytosol] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667626] RHEA:19455 [DatabaseIdentifier:9925793] RHEA:19455
dbId	70524
deleted	[Deleted:507778] Deletion of instance: 70525
displayName	PXLP-K314-GPT transaminates PYR to form L-Ala
eventOf	[Pathway:R-HSA-8964540] Alanine metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:507765] Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods [LiteratureReference:199767] Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. [LiteratureReference:507751] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-K314-GPT transaminates PYR to form L-Ala pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]
negativePrecedingEvent	[NegativePrecedingEvent:9930369] Futile Cycle: PXLP-K314-GPT transaminates L-Ala to form PYR
orthologousEvent	[Reaction:R-SCE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Saccharomyces cerevisiae [Reaction:R-SPO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Schizosaccharomyces pombe [Reaction:R-DDI-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Dictyostelium discoideum [Reaction:R-CEL-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Caenorhabditis elegans [Reaction:R-DME-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Drosophila melanogaster [Reaction:R-XTR-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Xenopus tropicalis [Reaction:R-DRE-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Danio rerio [Reaction:R-SSC-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Sus scrofa [Reaction:R-BTA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Bos taurus [Reaction:R-CFA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Canis familiaris [Reaction:R-RNO-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Rattus norvegicus [Reaction:R-MMU-70524] PXLP-K314-GPT transaminates PYR to form L-Ala - Mus musculus
output	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29432] L-Ala [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70524
summation	[Summation:179127] Cytosolic glutamic-pyruvate transaminase (alanine aminotrans...
updateTrackers	[UpdateTracker:9792299] Update Tracker - [Reaction:70524] PXLP-K314-GPT transaminates PYR to form L-Ala - v22:[addLiteratureReference] [UpdateTracker:9790822] Update Tracker - [Reaction:70524] PXLP-K314-GPT transaminates PYR to form L-Ala - v32:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792299] Update Tracker - [Reaction:70524] PXLP-K314-GPT transaminates PYR to form L-Ala - v22:[addLiteratureReference] [UpdateTracker:9790822] Update Tracker - [Reaction:70524] PXLP-K314-GPT transaminates PYR to form L-Ala - v32:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:507778] Deletion of instance: 70525
(hasEvent)	[Pathway:R-HSA-8964540] Alanine metabolism
(precedingEvent)	[NegativePrecedingEvent:9930399] Futile Cycle: PXLP-K314-GPT transaminates PYR to form L-Ala

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