Reactome | LDH tetramer oxidises LACT to PYR

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LDH tetramer oxidises LACT to PYR Show undefined attributes

catalystActivity	[CatalystActivity:10561324] L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10561329
displayName	LDH tetramer oxidises LACT to PYR
eventOf	[Pathway:R-DRE-70268] Pyruvate metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Danio rerio
inferredFrom	[Reaction:R-HSA-70510] LDH tetramer oxidises LACT to PYR - Homo sapiens
input	[SimpleEntity:R-ALL-29708] LACT [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LDH tetramer oxidises LACT to PYR (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
regulatedBy	[NegativeRegulation:10561330] Negative regulation by 'PolyUb-LDHA [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-70510
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-DRE-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
(inferredTo)	[Reaction:R-HSA-70510] LDH tetramer oxidises LACT to PYR

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