Reactome | Pyruvate kinase dephosphorylates PEP to PYR

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Pyruvate kinase dephosphorylates PEP to PYR Show undefined attributes

catalystActivity	[CatalystActivity:11052828] pyruvate kinase activity of pyruvate kinase tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11052833
displayName	Pyruvate kinase dephosphorylates PEP to PYR
eventOf	[Pathway:R-SPO-70268] Pyruvate metabolism - Schizosaccharomyces pombe [Pathway:R-SPO-70171] Glycolysis - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Homo sapiens
input	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pyruvate kinase dephosphorylates PEP to PYR phosphoenolpyruvate + ADP => pyruvate + ATP
output	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-SPO-71660] Enolase dimers dehydrates 2PG - Schizosaccharomyces pombe
regulatedBy	[NegativeRegulation:R-HSA-71661] Negative regulation by 'ATP [nucleoplasm]' [PositiveRegulation:R-HSA-71662] Positive regulation by 'F1,6PP [cytosol]' [NegativeRegulation:R-HSA-71663] Negative regulation by 'Ac-CoA [cytosol]' [NegativeRegulation:R-HSA-71664] Negative regulation by 'cAMP [cytosol]' [NegativeRegulation:11052834] Negative regulation by 'PolyUb-PKM-1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-71670
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-70268] Pyruvate metabolism [Pathway:R-SPO-70171] Glycolysis
(precedingEvent)	[Reaction:R-SPO-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
(inferredTo)	[Reaction:R-HSA-71670] Pyruvate kinase dephosphorylates PEP to PYR