Reactome | ME1 tetramer decarboxylates MAL to PYR

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ME1 tetramer decarboxylates MAL to PYR Show undefined attributes

authored	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
catalystActivity	[CatalystActivity:9012039] malate dehydrogenase (decarboxylating) (NADP+) activity of ME1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
crossReference	[DatabaseIdentifier:12667613] RHEA:18254 [DatabaseIdentifier:9861894] RHEA:18254
dbId	9012036
displayName	ME1 tetramer decarboxylates MAL to PYR
edited	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens
input	[SimpleEntity:R-ALL-198498] MAL [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012045] Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme [LiteratureReference:9012020] Structure and function of malic enzymes, a new class of oxidative decarboxylases [LiteratureReference:9012072] Structural characteristics of the nonallosteric human cytosolic malic enzyme [LiteratureReference:9012021] Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme [LiteratureReference:9761587] Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism [LiteratureReference:9861670] Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ME1 tetramer decarboxylates MAL to PYR ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
orthologousEvent	[Reaction:R-CEL-9012036] ME1 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-DME-9012036] ME1 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-GGA-9012036] ME1 tetramer decarboxylates MAL to PYR - Gallus gallus [Reaction:R-DRE-9012036] ME1 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-SSC-9012036] ME1 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-BTA-9012036] ME1 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-CFA-9012036] ME1 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-RNO-9012036] ME1 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-MMU-9012036] ME1 tetramer decarboxylates MAL to PYR - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens [Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Homo sapiens [Reaction:R-HSA-9861631] ME1 tetramerizes - Homo sapiens
regulatedBy	[NegativeRegulation:9861909] Negative regulation by 'p-S336-ME1 [cytosol]'
regulationReference	[RegulationReference:9861901] Negative regulation by 'p-S336-ME1 [cytosol]' Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036107] Hung, Hui-Chih, 2018-01-30 [InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9012036
summation	[Summation:9012025] NADP-dependent malic enzyme (ME1, aka c-NADP-ME) is a cytoso...
updateTrackers	[UpdateTracker:9864214] Update Tracker - [Reaction:9012036] ME1 tetramer decarboxylates MAL to PYR - v88:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864214] Update Tracker - [Reaction:9012036] ME1 tetramer decarboxylates MAL to PYR - v88:[addLiteratureReference, addRegulator, modifyText]
(precedingEvent)	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT
(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism

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