Reactome | PKM dephosphorylates PEP to PYR

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PKM dephosphorylates PEP to PYR Show undefined attributes

catalystActivity	[CatalystActivity:9866826] pyruvate kinase activity of pyruvate kinase tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9866831
displayName	PKM dephosphorylates PEP to PYR
eventOf	[Pathway:R-MMU-70268] Pyruvate metabolism - Mus musculus [Pathway:R-MMU-70171] Glycolysis - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-71849] LDH tetramer reduces PYR to LACT - Mus musculus [Reaction:R-MMU-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Mus musculus
inferredFrom	[Reaction:R-HSA-71670] PKM dephosphorylates PEP to PYR - Homo sapiens
input	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease	false
isInferred	true
name	PKM dephosphorylates PEP to PYR phosphoenolpyruvate + ADP => pyruvate + ATP
output	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-MMU-71660] 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O - Mus musculus
regulatedBy	[NegativeRegulation:R-HSA-71661] Negative regulation by 'ATP [nucleoplasm]' [PositiveRegulation:R-HSA-71662] Positive regulation by 'F1,6PP [cytosol]' [NegativeRegulation:R-HSA-71663] Negative regulation by 'Ac-CoA [cytosol]' [NegativeRegulation:R-HSA-71664] Negative regulation by 'cAMP [cytosol]' [NegativeRegulation:9866832] Negative regulation by 'PolyUb-PKM-1 [cytosol]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-71670
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-70268] Pyruvate metabolism [Pathway:R-MMU-70171] Glycolysis
(precedingEvent)	[Reaction:R-MMU-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-MMU-71849] LDH tetramer reduces PYR to LACT
(inferredTo)	[Reaction:R-HSA-71670] PKM dephosphorylates PEP to PYR