Reactome | PXLP-K314-GPT transaminates L-Ala to form PYR

Schema > Reaction > Entries

PXLP-K314-GPT transaminates L-Ala to form PYR Show undefined attributes

catalystActivity	[CatalystActivity:70522] L-alanine:2-oxoglutarate aminotransferase activity of PXLP-K314-GPT dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643950] L-alanine:2-oxoglutarate aminotransferase activity of GPT dimer [cytosol] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667625] RHEA:19454 [DatabaseIdentifier:9861843] RHEA:19454
dbId	70523
deleted	[Deleted:507778] Deletion of instance: 70525
displayName	PXLP-K314-GPT transaminates L-Ala to form PYR
eventOf	[Pathway:R-HSA-8964540] Alanine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29432] L-Ala [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:507765] Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods [LiteratureReference:199767] Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. [LiteratureReference:507751] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-K314-GPT transaminates L-Ala to form PYR alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]
negativePrecedingEvent	[NegativePrecedingEvent:9930399] Futile Cycle: PXLP-K314-GPT transaminates PYR to form L-Ala
orthologousEvent	[Reaction:R-SCE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Saccharomyces cerevisiae [Reaction:R-SPO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Schizosaccharomyces pombe [Reaction:R-DDI-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Dictyostelium discoideum [Reaction:R-CEL-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Caenorhabditis elegans [Reaction:R-DME-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Drosophila melanogaster [Reaction:R-XTR-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Xenopus tropicalis [Reaction:R-DRE-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Danio rerio [Reaction:R-SSC-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Sus scrofa [Reaction:R-BTA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Bos taurus [Reaction:R-CFA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Canis familiaris [Reaction:R-RNO-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Rattus norvegicus [Reaction:R-MMU-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Mus musculus
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70523
summation	[Summation:178457] Cytosolic glutamic-pyruvate transaminase (alanine aminotrans...
updateTrackers	[UpdateTracker:9790971] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792352] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790971] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792352] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v22:[addLiteratureReference]
(replacementInstances)	[Deleted:507778] Deletion of instance: 70525
(hasEvent)	[Pathway:R-HSA-8964540] Alanine metabolism [Pathway:R-HSA-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT [Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [NegativePrecedingEvent:9930369] Futile Cycle: PXLP-K314-GPT transaminates L-Ala to form PYR
(reverseReaction)	[Reaction:R-HSA-70524] PXLP-K314-GPT transaminates PYR to form L-Ala

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