Reactome | NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate

Schema > Reaction > Entries

NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate Show undefined attributes

catalystActivity	[CatalystActivity:10608537] N-acetylneuraminate lyase activity of NPL tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10608539
displayName	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate
eventOf	[Pathway:R-DRE-4085001] Sialic acid metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-6803761] RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc - Danio rerio
inferredFrom	[Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Homo sapiens
input	[DefinedSet:R-ALL-4088096] Neu5Ac, Neu5Gc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate
output	[DefinedSet:R-ALL-4088099] ManNAc,ManNGc [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-DRE-428585] SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol - Danio rerio [Reaction:R-DRE-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Danio rerio [Reaction:R-DRE-4084994] NEU3 hydrolyzes Neu5Ac from glycoconjugates - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-4085217
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-4085001] Sialic acid metabolism
(precedingEvent)	[Reaction:R-DRE-6803761] RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc
(inferredTo)	[Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate

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