Reactome | Cysteine is degraded to pyruvate and H2S

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Cysteine is degraded to pyruvate and H2S Show undefined attributes

authored	[InstanceEdit:1237120] Stephan, R, 2010-10-24
catalystActivity	[CatalystActivity:1614529] carbon-sulfur lyase activity of PXLP-K212-CTH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
crossReference	[DatabaseIdentifier:12667656] RHEA:24932 [DatabaseIdentifier:9929700] RHEA:24932
dbId	1614614
displayName	Cysteine is degraded to pyruvate and H2S
edited	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
eventOf	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine - Homo sapiens
followingEvent	[Reaction:R-HSA-1614665] SQR oxidizes sulfide to bound persulfide - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111707] L-Cys [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1614602] H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia [LiteratureReference:1625216] Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Cysteine is degraded to pyruvate and H2S H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate
orthologousEvent	[Reaction:R-SCE-1614614] Cysteine is degraded to pyruvate and H2S - Saccharomyces cerevisiae [Reaction:R-SPO-1614614] Cysteine is degraded to pyruvate and H2S - Schizosaccharomyces pombe [Reaction:R-DDI-1614614] Cysteine is degraded to pyruvate and H2S - Dictyostelium discoideum [Reaction:R-CEL-1614614] Cysteine is degraded to pyruvate and H2S - Caenorhabditis elegans [Reaction:R-DME-1614614] Cysteine is degraded to pyruvate and H2S - Drosophila melanogaster [Reaction:R-GGA-1614614] Cysteine is degraded to pyruvate and H2S - Gallus gallus [Reaction:R-XTR-1614614] Cysteine is degraded to pyruvate and H2S - Xenopus tropicalis [Reaction:R-DRE-1614614] Cysteine is degraded to pyruvate and H2S - Danio rerio [Reaction:R-SSC-1614614] Cysteine is degraded to pyruvate and H2S - Sus scrofa [Reaction:R-BTA-1614614] Cysteine is degraded to pyruvate and H2S - Bos taurus [Reaction:R-CFA-1614614] Cysteine is degraded to pyruvate and H2S - Canis familiaris [Reaction:R-RNO-1614614] Cysteine is degraded to pyruvate and H2S - Rattus norvegicus [Reaction:R-MMU-1614614] Cysteine is degraded to pyruvate and H2S - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1614532] H2S [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-HSA-1614583] PXLP-K212-CTH cleaves L-Cystathionine - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1614614
summation	[Summation:1614662] Alpha,beta-elimination activity of cystathionine-gamma-lyase...
updateTrackers	[UpdateTracker:9939672] Update Tracker - [Reaction:1614614] Cysteine is degraded to pyruvate and H2S - v92:[add_removeOutput, modifyText]

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(updatedInstance)	[UpdateTracker:9939672] Update Tracker - [Reaction:1614614] Cysteine is degraded to pyruvate and H2S - v92:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine
(precedingEvent)	[Reaction:R-HSA-1614665] SQR oxidizes sulfide to bound persulfide