Reactome | PXLP-K56-SRR dimer deaminates D-Ser

Schema > Reaction > Entries

PXLP-K56-SRR dimer deaminates D-Ser Show undefined attributes

authored	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
catalystActivity	[CatalystActivity:9014746] D-serine ammonia-lyase activity of PXLP-K56-SRR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
crossReference	[DatabaseIdentifier:12667715] RHEA:13978 [DatabaseIdentifier:9929627] RHEA:13978
dbId	9014741
displayName	PXLP-K56-SRR dimer deaminates D-Ser
edited	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
eventOf	[Pathway:R-HSA-977347] Serine metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-376186] D-Ser [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9014756] Serine racemase: a key player in apoptosis and necrosis [LiteratureReference:9014748] Human serine racemase: moleular cloning, genomic organization and functional analysis [LiteratureReference:9014781] Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine [LiteratureReference:9014735] Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity [LiteratureReference:9014770] The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-K56-SRR dimer deaminates D-Ser D-serine => NH4(+) + pyruvate
orthologousEvent	[Reaction:R-SCE-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Saccharomyces cerevisiae [Reaction:R-SPO-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Schizosaccharomyces pombe [Reaction:R-DDI-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Dictyostelium discoideum [Reaction:R-CEL-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Caenorhabditis elegans [Reaction:R-GGA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Gallus gallus [Reaction:R-XTR-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Xenopus tropicalis [Reaction:R-SSC-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Sus scrofa [Reaction:R-BTA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Bos taurus [Reaction:R-CFA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Canis familiaris [Reaction:R-RNO-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Rattus norvegicus [Reaction:R-MMU-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Mus musculus
output	[SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-HSA-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:R-HSA-9014736] Positive regulation by 'ATP [cytosol]' [PositiveRegulation:R-HSA-9014755] Positive regulation by 'Mg2+ [cytosol]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9034652] Wolosker, Herman, 2018-01-09 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014741
summation	[Summation:9014759] N-methyl D-aspartate (NMDA) receptors play a key role in exc...
updateTrackers	[UpdateTracker:9939793] Update Tracker - [Reaction:9014741] PXLP-K56-SRR dimer deaminates D-Ser - v92:[add_removeOutput, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9939793] Update Tracker - [Reaction:9014741] PXLP-K56-SRR dimer deaminates D-Ser - v92:[add_removeOutput, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-977347] Serine metabolism