Reactome | PXLP-K314-GPT transaminates L-Ala to form PYR

Schema > Reaction > Entries

PXLP-K314-GPT transaminates L-Ala to form PYR Show undefined attributes

catalystActivity	[CatalystActivity:10334399] L-alanine:2-oxoglutarate aminotransferase activity of PXLP-K314-GPT dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334401
displayName	PXLP-K314-GPT transaminates L-Ala to form PYR
eventOf	[Pathway:R-BTA-70268] Pyruvate metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-71849] LDH tetramer reduces PYR to LACT - Bos taurus [Reaction:R-BTA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Bos taurus
inferredFrom	[Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29432] L-Ala [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K314-GPT transaminates L-Ala to form PYR alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-70523
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-70268] Pyruvate metabolism [Pathway:R-BTA-8964540] Alanine metabolism
(precedingEvent)	[Reaction:R-BTA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-BTA-71849] LDH tetramer reduces PYR to LACT
(inferredTo)	[Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR

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