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Schema
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Reaction
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Entries
PKM dephosphorylates PEP to PYR
Show undefined attributes
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authored
[InstanceEdit:141518] D'Eustachio, P, 2004-09-21 15:25:22
catalystActivity
[CatalystActivity:71669] pyruvate kinase activity of pyruvate kinase tetramer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643408] pyruvate kinase activity of pyruvate kinase tetramer [cytosol] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:9861809] RHEA:18159
[DatabaseIdentifier:11880213] Rhea:18159
dbId
71670
displayName
PKM dephosphorylates PEP to PYR
eventOf
[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent
[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens
[Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens
[Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens
input
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:450664] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
[LiteratureReference:450661] cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia
[LiteratureReference:450640] Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
[LiteratureReference:141473] Isolation and characterization of the human pyruvate kinase M gene
[LiteratureReference:141558] Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells
[LiteratureReference:450635] Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia
[LiteratureReference:450637] Red cell pyruvate kinase deficiency: molecular and clinical aspects
[LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
PKM dephosphorylates PEP to PYR
phosphoenolpyruvate + ADP => pyruvate + ATP
orthologousEvent
[Reaction:R-MMU-71670] PKM dephosphorylates PEP to PYR - Mus musculus
[Reaction:R-RNO-71670] PKM dephosphorylates PEP to PYR - Rattus norvegicus
[Reaction:R-CFA-71670] PKM dephosphorylates PEP to PYR - Canis familiaris
[Reaction:R-BTA-71670] PKM dephosphorylates PEP to PYR - Bos taurus
[Reaction:R-SSC-71670] PKM dephosphorylates PEP to PYR - Sus scrofa
[Reaction:R-DRE-71670] PKM dephosphorylates PEP to PYR - Danio rerio
[Reaction:R-XTR-71670] PKM dephosphorylates PEP to PYR - Xenopus tropicalis
[Reaction:R-GGA-71670] PKM dephosphorylates PEP to PYR - Gallus gallus
[Reaction:R-DME-71670] PKM dephosphorylates PEP to PYR - Drosophila melanogaster
[Reaction:R-CEL-71670] PKM dephosphorylates PEP to PYR - Caenorhabditis elegans
[Reaction:R-DDI-71670] PKM dephosphorylates PEP to PYR - Dictyostelium discoideum
[Reaction:R-SPO-71670] PKM dephosphorylates PEP to PYR - Schizosaccharomyces pombe
[Reaction:R-SCE-71670] PKM dephosphorylates PEP to PYR - Saccharomyces cerevisiae
[Reaction:R-PFA-71670] PKM dephosphorylates PEP to PYR - Plasmodium falciparum
output
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent
[Reaction:R-HSA-71660] 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O - Homo sapiens
[BlackBoxEvent:R-HSA-163669] Transcriptional activation of PKLR gene by ChREBP:MLX - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeRegulation:R-HSA-71661] Negative regulation by 'ATP [nucleoplasm]'
[PositiveRegulation:R-HSA-71662] Positive regulation by 'F1,6PP [cytosol]'
[NegativeRegulation:R-HSA-71663] Negative regulation by 'Ac-CoA [cytosol]'
[NegativeRegulation:R-HSA-71664] Negative regulation by 'cAMP [cytosol]'
[NegativeRegulation:9861890] Negative regulation by 'PolyUb-PKM-1 [cytosol]'
regulationReference
[RegulationReference:9861891] Negative regulation by 'PolyUb-PKM-1 [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9862191] Hill, David P, 2024-02-23
revised
[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-71670
summation
[Summation:141540] Cytosolic pyruvate kinase catalyzes the transfer of a high-e...
Referrals
(precedingEvent)
[Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT
[Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix
(hasEvent)
[Pathway:R-HSA-70171] Glycolysis
[Pathway:R-HSA-70268] Pyruvate metabolism
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