Reactome | Pyruvate kinase dephosphorylates PEP to PYR

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Pyruvate kinase dephosphorylates PEP to PYR Show undefined attributes

authored	[InstanceEdit:141518] D'Eustachio, P, 2004-09-21 15:25:22
catalystActivity	[CatalystActivity:71669] pyruvate kinase activity of pyruvate kinase tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643408] pyruvate kinase activity of pyruvate kinase tetramer [cytosol] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9861809] RHEA:18159 [DatabaseIdentifier:12667617] RHEA:18159
dbId	71670
deleted	[Deleted:450677] Deletion of instance: 70102 [Deleted:450678] Deletion of instance: 70100
displayName	Pyruvate kinase dephosphorylates PEP to PYR
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens [Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent	[Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens
input	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450664] Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis [LiteratureReference:450661] cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia [LiteratureReference:450640] Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription [LiteratureReference:141473] Isolation and characterization of the human pyruvate kinase M gene [LiteratureReference:141558] Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells [LiteratureReference:450635] Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia [LiteratureReference:450637] Red cell pyruvate kinase deficiency: molecular and clinical aspects [LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Pyruvate kinase dephosphorylates PEP to PYR phosphoenolpyruvate + ADP => pyruvate + ATP
orthologousEvent	[Reaction:R-MMU-71670] Pyruvate kinase dephosphorylates PEP to PYR - Mus musculus [Reaction:R-RNO-71670] Pyruvate kinase dephosphorylates PEP to PYR - Rattus norvegicus [Reaction:R-CFA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Canis familiaris [Reaction:R-BTA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Bos taurus [Reaction:R-SSC-71670] Pyruvate kinase dephosphorylates PEP to PYR - Sus scrofa [Reaction:R-DRE-71670] Pyruvate kinase dephosphorylates PEP to PYR - Danio rerio [Reaction:R-XTR-71670] Pyruvate kinase dephosphorylates PEP to PYR - Xenopus tropicalis [Reaction:R-GGA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Gallus gallus [Reaction:R-DME-71670] Pyruvate kinase dephosphorylates PEP to PYR - Drosophila melanogaster [Reaction:R-CEL-71670] Pyruvate kinase dephosphorylates PEP to PYR - Caenorhabditis elegans [Reaction:R-DDI-71670] Pyruvate kinase dephosphorylates PEP to PYR - Dictyostelium discoideum [Reaction:R-SPO-71670] Pyruvate kinase dephosphorylates PEP to PYR - Schizosaccharomyces pombe [Reaction:R-SCE-71670] Pyruvate kinase dephosphorylates PEP to PYR - Saccharomyces cerevisiae [Reaction:R-PFA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Plasmodium falciparum
output	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-HSA-71660] Enolase dimers dehydrates 2PG - Homo sapiens [BlackBoxEvent:R-HSA-163669] Transcriptional activation of PKLR gene by ChREBP:MLX - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:R-HSA-71661] Negative regulation by 'ATP [nucleoplasm]' [PositiveRegulation:R-HSA-71662] Positive regulation by 'F1,6PP [cytosol]' [NegativeRegulation:R-HSA-71663] Negative regulation by 'Ac-CoA [cytosol]' [NegativeRegulation:R-HSA-71664] Negative regulation by 'cAMP [cytosol]' [NegativeRegulation:9861890] Negative regulation by 'PolyUb-PKM-1 [cytosol]'
regulationReference	[RegulationReference:9861891] Negative regulation by 'PolyUb-PKM-1 [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71670
summation	[Summation:141540] Cytosolic pyruvate kinase catalyzes the transfer of a high-e...
updateTrackers	[UpdateTracker:9791199] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v32:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9864338] Update Tracker - [Reaction:71670] PKM dephosphorylates PEP to PYR - v88:[addLiteratureReference, addRegulator] [UpdateTracker:9777291] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v72:[addInput]

Referrals

(precedingEvent)	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT
(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism [Pathway:R-HSA-70171] Glycolysis
(replacementInstances)	[Deleted:450677] Deletion of instance: 70102 [Deleted:450678] Deletion of instance: 70100
(updatedInstance)	[UpdateTracker:9791199] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v32:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9864338] Update Tracker - [Reaction:71670] PKM dephosphorylates PEP to PYR - v88:[addLiteratureReference, addRegulator] [UpdateTracker:9777291] Update Tracker - [Reaction:71670] phosphoenolpyruvate + ADP => pyruvate + ATP - v72:[addInput]

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