Reactome | MeSec is hydrolysed to MeSeH by PXLP-K212-CTH

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MeSec is hydrolysed to MeSeH by PXLP-K212-CTH Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359025] methylselenocysteine deselenhydrase activity of PXLP-K212-CTH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408539
displayName	MeSec is hydrolysed to MeSeH by PXLP-K212-CTH
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Homo sapiens
followingEvent	[Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase - Homo sapiens [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens
inferredFrom	[Reaction:R-RNO-2408538] MeSec is hydrolysed to MeSeH by PXLP-K211-Cth - Rattus norvegicus
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5357710] MeSec [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5359220] Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds [LiteratureReference:5359227] Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide
maxDepth	1
modified	[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	MeSec is hydrolysed to MeSeH by PXLP-K212-CTH
output	[SimpleEntity:R-ALL-5357669] MeSeH [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408539
summation	[Summation:5422903] Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimin...
updateTrackers	[UpdateTracker:9939667] Update Tracker - [Reaction:2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH - v92:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9939667] Update Tracker - [Reaction:2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH - v92:[add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase
(hasEvent)	[Pathway:R-HSA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se
(inferredTo)	[Reaction:R-RNO-2408538] MeSec is hydrolysed to MeSeH by PXLP-K211-Cth

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