Reactome | LDH tetramer reduces PYR to LACT

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LDH tetramer reduces PYR to LACT Show undefined attributes

catalystActivity	[CatalystActivity:10915694] L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10916872
displayName	LDH tetramer reduces PYR to LACT
eventOf	[Pathway:R-CEL-70268] Pyruvate metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LDH tetramer reduces PYR to LACT Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+
output	[SimpleEntity:R-ALL-29708] LACT [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
precedingEvent	[Reaction:R-CEL-71670] Pyruvate kinase dephosphorylates PEP to PYR - Caenorhabditis elegans [Reaction:R-CEL-9012036] ME1 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-CEL-9861660] ME1 tetramer decarboxylates OA to PYR - Caenorhabditis elegans [Reaction:R-CEL-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Caenorhabditis elegans
regulatedBy	[NegativeRegulation:10915700] Negative regulation by 'PolyUb-LDHA [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-71849
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-CEL-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
(inferredTo)	[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT