Reactome | ME1 tetramer decarboxylates OA to PYR

Schema > Reaction > Entries

ME1 tetramer decarboxylates OA to PYR Show undefined attributes

authored	[InstanceEdit:9861713] Stephan, Ralf, 2024-01-25
catalystActivity	[CatalystActivity:9861583] oxaloacetate decarboxylase activity of ME1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
crossReference	[DatabaseIdentifier:12667621] RHEA:15642 [DatabaseIdentifier:9861641] RHEA:15642
dbId	9861660
displayName	ME1 tetramer decarboxylates OA to PYR
edited	[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-76213] OA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9861670] Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain [LiteratureReference:9012045] Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme [LiteratureReference:9012020] Structure and function of malic enzymes, a new class of oxidative decarboxylases [LiteratureReference:9012072] Structural characteristics of the nonallosteric human cytosolic malic enzyme [LiteratureReference:9012021] Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ME1 tetramer decarboxylates OA to PYR
orthologousEvent	[Reaction:R-CEL-9861660] ME1 tetramer decarboxylates OA to PYR - Caenorhabditis elegans [Reaction:R-DME-9861660] ME1 tetramer decarboxylates OA to PYR - Drosophila melanogaster [Reaction:R-GGA-9861660] ME1 tetramer decarboxylates OA to PYR - Gallus gallus [Reaction:R-DRE-9861660] ME1 tetramer decarboxylates OA to PYR - Danio rerio [Reaction:R-SSC-9861660] ME1 tetramer decarboxylates OA to PYR - Sus scrofa [Reaction:R-BTA-9861660] ME1 tetramer decarboxylates OA to PYR - Bos taurus [Reaction:R-CFA-9861660] ME1 tetramer decarboxylates OA to PYR - Canis familiaris [Reaction:R-RNO-9861660] ME1 tetramer decarboxylates OA to PYR - Rattus norvegicus [Reaction:R-MMU-9861660] ME1 tetramer decarboxylates OA to PYR - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
precedingEvent	[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens [Reaction:R-HSA-9861631] ME1 tetramerizes - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9861660
summation	[Summation:9861633] Cytosolic malic enzyme (ME1, aka c-NADP-ME) oxidatively deca...

Referrals

(precedingEvent)	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT
(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism

Cite Us!