Reactome | LDH tetramer oxidises LACT to PYR

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LDH tetramer oxidises LACT to PYR Show undefined attributes

catalystActivity	[CatalystActivity:70509] L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643670] L-lactate dehydrogenase activity of LDH tetramer [cytosol] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667627] RHEA:23445 [DatabaseIdentifier:9861806] RHEA:23445
dbId	70510
displayName	LDH tetramer oxidises LACT to PYR
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens
input	[SimpleEntity:R-ALL-29708] LACT [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807598] Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) [LiteratureReference:6807523] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli [LiteratureReference:6808368] Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence [LiteratureReference:179539] Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase [LiteratureReference:179533] The cDNA and protein sequences of human lactate dehydrogenase B [LiteratureReference:179524] Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 [LiteratureReference:9861797] The Biochemical and Clinical Perspectives of Lactate Dehydrogenase: An Enzyme of Active Metabolism [LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	LDH tetramer oxidises LACT to PYR (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
negativePrecedingEvent	[NegativePrecedingEvent:9908917] Futile Cycle: LDH tetramer reduces PYR to LACT
orthologousEvent	[Reaction:R-CEL-70510] LDH tetramer oxidises LACT to PYR - Caenorhabditis elegans [Reaction:R-DME-70510] LDH tetramer oxidises LACT to PYR - Drosophila melanogaster [Reaction:R-GGA-70510] LDH tetramer oxidises LACT to PYR - Gallus gallus [Reaction:R-XTR-70510] LDH tetramer oxidises LACT to PYR - Xenopus tropicalis [Reaction:R-DRE-70510] LDH tetramer oxidises LACT to PYR - Danio rerio [Reaction:R-SSC-70510] LDH tetramer oxidises LACT to PYR - Sus scrofa [Reaction:R-BTA-70510] LDH tetramer oxidises LACT to PYR - Bos taurus [Reaction:R-CFA-70510] LDH tetramer oxidises LACT to PYR - Canis familiaris [Reaction:R-RNO-70510] LDH tetramer oxidises LACT to PYR - Rattus norvegicus [Reaction:R-MMU-70510] LDH tetramer oxidises LACT to PYR - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-29398] PYR [cytosol]
regulatedBy	[NegativeRegulation:9861807] Negative regulation by 'PolyUb-LDHA [cytosol]'
regulationReference	[RegulationReference:9861794] Negative regulation by 'PolyUb-LDHA [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809181] Jassal, Bijay, 2015-11-09 [InstanceEdit:9862191] Hill, David P, 2024-02-23
revised	[InstanceEdit:450856] D'Eustachio, P, 2009-12-18 [InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70510
summation	[Summation:70511] Cytosolic lactate dehydrogenase (LDH) catalyzes the freely r...
updateTrackers	[UpdateTracker:9791083] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v32:[modifyText] [UpdateTracker:9784000] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v55:[addLiteratureReference, modifyText] [UpdateTracker:9864273] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v88:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791083] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v32:[modifyText] [UpdateTracker:9784000] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v55:[addLiteratureReference, modifyText] [UpdateTracker:9864273] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v88:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [NegativePrecedingEvent:9908919] Futile Cycle: LDH tetramer oxidises LACT to PYR
(reverseReaction)	[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT

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