Reactome | Negative Regulation of CDH1 Gene Transcription

Negative Regulation of CDH1 Gene Transcription

Stable Identifier

R-HSA-9764725

Type

Pathway

Species

Homo sapiens

ReviewStatus

3/5

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)

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Negative Regulation of CDH1 Gene Transcription

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Numerous transcription factors have been identified as direct negative regulators of transcription of CDH1 gene (also known as E-cadherin, epithelial cadherin, Cadherin-1, CADH1, or uvomorulin). Only those transcription factors reported to repress CDH1 gene transcription in at least two studies, in at least one directly, have been annotated in this pathway. These include CTBP1 (Cowger et al. 2007, Bruton et al. 2008; Deng et al. 2012; Deng et al. 2014) and CTBP2 (Zhao et al. 2007; Lee et al. 2011), DNTTIP1 (Liu et al. 2021; Wang et al. 2023), FOXQ1 (Zhang et al. 2011, Pei et al. 2015), the polycomb repressor complex PRC2 (EZH2) (Herranz et al. 2008; Oktyabri et al. 2014; Tien et al. 2015; Nolan et al. 2015; Pan et al. 2015; Rajabi et al. 2017), SNAI1 (SNAIL) (Cano et al. 2000; Batlle et al. 2000; Peinado et la. 2004; Herranz et al. 2008; Hou et al. 2010; Dong et al. 2013; Lu et al. 2014; Villarejo et al. 2014; Maturi et al. 2018), SNAI2 (SLUG) (Hajra et al. 2002; Hayashida et al, 2006; Saito et al. 2004; Saito et al, 2006; Ferrari-Amorotti et al. 2013; Villarejo et al. 2014), TCF3 (Cubillo et al. 2013; Zhu et al. 2016; Xu et al. 2021), TCF12 (Lee et al. 2012; Chen et al. 2013), TGIF2 (Hamabe et al. 2014; Yang et al. 2022), TWIST1 (Vesuna et al. 2008, Yang et al. 2012), TWIST2 (Yang et al. 2016, Wang et al. 2021), WT1 (Brett et al. 2013; Wu et al. 2013; Han et al. 2020), ZBTB33 (Jones et al. 2012, Jones et al. 2014), ZEB1 (Kokura et al. 2010; Mazda et al. 2011; Aghdassi et al. 2012; Hou et al. 2016; Sun et al. 2015; Yao et al. 2017; ), ZEB2 (Ghoumid et al. 2013; He et al. 2017), and ZNF217 (Cowger et al. 2007, Nunez et al. 2011, Si et al. 2019).

Transcription factors implicated in direct repression of CDH1 gene transcription by a single study are not shown in the pathway diagram. These include AR (Liu et al. 2008), SOX30 (Han et al. 2019), GATA1 (Li et al. 2015), MIER3 (Huang et al. 2021), TBX3 (Rodriguez et al. 2008), KLF8 (Wang et al. 2007), and GRHL3 (Zhao et al. 2016).

Hepatitis B virus (HBV)-encoded X antigen (HBx) downregulates CDH1 gene transcription by recruiting the SIN3A:HDAC histone deacetylase complex to the Snail-binding sites in the human CDH1 gene promoter (Arzumanyan et al. 2012). Hepatitis C virus (HCV) core protein facilitates binding of SNAI1 to the CDH1 gene promoter and the consequent downregulation of CDH1 gene transcription (Nie et al. 2016). Hexavalent chromium Cr(VI), a carcinogen associated with lung diseases and lung cancer, represses CDH1 gene expression through activation of CDH1 gene repressors such as SNAI1, ZEB1, and KLF8, and enhancing the binding of HDAC1 to the CDH1 gene promoter (Ding et al. 2013).

Downregulation of the CDH1 gene expression is one of the hallmarks of epithelial-to-mesenchymal transition, seen normally during development and wound healing, but also pathologically, during cancer progression (reviewed in Serrano-Gomez et al. 2016). Expression of many negative regulators of the CDH1 gene is controlled by TGF-beta signaling (Peinado et al. 2003; Choi et al. 2007; Vincent et al. 2009; Brandl et al. 2010), prostaglandin E(2) signaling (Dohadwala et al. 2006), WNT signaling (Huang et al. 2008; Khan et al. 2013), and NFκB signaling (Julien et al. 2007; Brandl et al. 2010; Hung et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
35292107	PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition Yang, Y, Ren, P, Liu, X, Sun, X, Zhang, C, Du, X, Xing, B	J Exp Clin Cancer Res	2022
34462424	Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition Xu, S, Mo, C, Lin, J, Yan, Y, Liu, X, Wu, K, Zhang, H, Zhu, Y, Chen, L, Chen, X	Cell Death Discov	2021
22974583	Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells Jones, J, Wang, H, Zhou, J, Hardy, S, Turner, T, Austin, D, He, Q, Wells, A, Grizzle, WE, Yates, C	Am J Pathol	2012
21681822	Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer Deng, Y, Deng, H, Liu, J, Han, G, Malkoski, S, Liu, B, Zhao, R, Wang, XJ, Zhang, Q	Mol Carcinog	2012
16707460	Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer Dohadwala, M, Yang, SC, Luo, J, Sharma, S, Batra, RK, Huang, M, Lin, Y, Goodglick, L, Krysan, K, Fishbein, MC, Hong, L, Lai, C, Cameron, RB, Gemmill, RM, Drabkin, HA, Dubinett, SM	Cancer Res	2006
21315774	Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter Lee, S, Hong, S, Kim, S, Kang, S	Biochim Biophys Acta	2011
24570268	Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas Jones, J, Wang, H, Karanam, B, Theodore, S, Dean-Colomb, W, Welch, DR, Grizzle, W, Yates, C	Clin Exp Metastasis	2014
22130667	TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer Lee, CC, Chen, WS, Chen, CC, Chen, LL, Lin, YS, Fan, CS, Huang, TS	J Biol Chem	2012
17525203	Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells Choi, J, Park, SY, Joo, CK	Invest Ophthalmol Vis Sci	2007
29729076	Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells Maturi, V, Morén, A, Enroth, S, Heldin, CH, Moustakas, A	Mol Oncol	2018
34242623	MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail Huang, W, Chen, J, Liu, X, Liu, X, Duan, S, Chen, L, Liu, X, Lan, J, Zou, Y, Guo, D, Zhou, J	Exp Cell Res	2021
30608899	SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer Han, F, Liu, WB, Li, JJ, Zhang, MQ, Yang, JT, Zhang, X, Hao, XL, Yin, L, Mao, CY, Jiang, X, Cao, J, Liu, JY	Endocr Relat Cancer	2019
30898548	The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101 Si, W, Zhao, Y, Zhou, J, Zhang, Q, Zhang, Y	Exp Cell Res	2019
20501852	14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation Hou, Z, Peng, H, White, DE, Wang, P, Lieberman, PM, Halazonetis, T, Rauscher, FJ	Cancer Res	2010
25726523	GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling Li, Y, Ke, Q, Shao, Y, Zhu, G, Li, Y, Geng, N, Jin, F, Li, F	Oncotarget	2015
11912130	The SLUG zinc-finger protein represses E-cadherin in breast cancer Hajra, KM, Chen, DY, Fearon, ER	Cancer Res	2002
21983900	SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities Yang, F, Sun, L, Li, Q, Han, X, Lei, L, Zhang, H, Shang, Y	EMBO J	2012
25617436	Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development Tien, CL, Jones, A, Wang, H, Gerigk, M, Nozell, S, Chang, C	Development	2015
21908891	The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain Nunez, N, Clifton, MMK, Funnell, APW, Artuz, C, Hallal, S, Quinlan, KGR, Font, J, Vandevenne, M, Setiyaputra, S, Pearson, RCM, Mackay, JP, Crossley, M	J Biol Chem	2011
36636625	High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma Wang, X, Li, W, Lou, N, Han, W, Hai, B, Xiao, W, Zhang, X	Pharmgenomics Pers Med	2023
32892698	Wilms' tumor 1 (WT1) promotes ovarian cancer progression by regulating E-cadherin and ERK1/2 signaling Han, Y, Song, C, Zhang, T, Zhou, Q, Zhang, X, Wang, J, Xu, B, Zhang, X, Liu, X, Ying, X	Cell Cycle	2020
18062917	Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer Vesuna, F, van Diest, P, Chen, JH, Raman, V	Biochem Biophys Res Commun	2008
18829543	Tbx3 represses E-cadherin expression and enhances melanoma invasiveness Rodriguez, M, Aladowicz, E, Lanfrancone, L, Goding, CR	Cancer Res	2008
26688070	G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation Pan, MR, Hsu, MC, Chen, LT, Hung, WC	Sci Rep	2015
18519590	Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor Herranz, N, Pasini, D, Diaz, VM, Francí, C, Gutierrez, A, Dave, N, Escrivà, M, Hernandez-Muñoz, I, Di Croce, L, Helin, K, García de Herreros, A, Peiró, S	Mol Cell Biol	2008
18321996	Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 Huang, W, Zhang, Y, Varambally, S, Chinnaiyan, AM, Banerjee, M, Merajver, SD, Kleer, CG	Am J Pathol	2008
25264103	EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β Oktyabri, D, Tange, S, Terashima, M, Ishimura, A, Suzuki, T	Biochem Biophys Res Commun	2014
17671186	Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion Wang, X, Zheng, M, Liu, G, Xia, W, McKeown-Longo, PJ, Hung, MC, Zhao, J	Cancer Res	2007
25870236	MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition Sun, L, Kokura, K, Izumi, V, Koomen, JM, Seto, E, Chen, J, Fang, J	EMBO Rep	2015
17546044	PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions Zhao, LJ, Subramanian, T, Vijayalingam, S, Chinnadurai, G	Oncogene	2007
23466526	ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome Ghoumid, J, Drevillon, L, Alavi-Naini, SM, Bondurand, N, Rio, M, Briand-Suleau, A, Nasser, M, Goodwin, L, Raymond, P, Yanicostas, C, Goossens, M, Lyonnet, S, Mowat, D, Amiel, J, Soussi-Yanicostas, N, Giurgea, I	Hum Mol Genet	2013
23945386	WT1 promotes invasion of NSCLC via suppression of CDH1 Wu, C, Zhu, W, Qian, J, He, S, Wu, C, Chen, Y, Shu, Y	J Thorac Oncol	2013
28785086	MUC1-C activates EZH2 expression and function in human cancer cells Rajabi, H, Hiraki, M, Tagde, A, Alam, M, Bouillez, A, Christensen, CL, Samur, M, Wong, KK, Kufe, D	Sci Rep	2017
23386606	Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion Chen, WS, Chen, CC, Chen, LL, Lee, CC, Huang, TS	J Biol Chem	2013
35008676	TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer Liu, Q, Xiong, J, Xu, D, Hao, N, Zhang, Y, Sang, Y, Wang, Z, Zheng, X, Min, J, Diao, H, Raphael, J, Maleki Vareki, S, Koropatnick, J, Min, W	Int J Mol Sci	2021
26842802	HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer Yang, J, Zhang, X, Zhang, Y, Zhu, D, Zhang, L, Li, Y, Zhu, Y, Li, D, Zhou, J	J Exp Clin Cancer Res	2016
25313085	Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition Hamabe, A, Konno, M, Tanuma, N, Shima, H, Tsunekuni, K, Kawamoto, K, Nishida, N, Koseki, J, Mimori, K, Gotoh, N, Yamamoto, H, Doki, Y, Mori, M, Ishii, H	Proc Natl Acad Sci U S A	2014
21706058	Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer Arzumanyan, A, Friedman, T, Kotei, E, Ng, IO, Lian, Z, Feitelson, MA	Oncogene	2012
16943193	Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug Hayashida, Y, Urata, Y, Muroi, E, Kono, T, Miyata, Y, Nomata, K, Kanetake, H, Kondo, T, Ihara, Y	J Biol Chem	2006
21081648	IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells Brandl, M, Seidler, B, Haller, F, Adamski, J, Schmid, RM, Saur, D, Schneider, G	J Cell Sci	2010
23054398	Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion Ferrari-Amorotti, G, Fragliasso, V, Esteki, R, Prudente, Z, Soliera, AR, Cattelani, S, Manzotti, G, Grisendi, G, Dominici, M, Pieraccioli, M, Raschella, G, Chiodoni, C, Colombo, MP, Calabretta, B	Cancer Res	2013
22205962	E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing Mazda, M, Nishi, K, Naito, Y, Ui-Tei, K	PLoS One	2011
22147512	Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer Aghdassi, A, Sendler, M, Guenther, A, Mayerle, J, Behn, CO, Heidecke, CD, Friess, H, Büchler, M, Evert, M, Lerch, MM, Weiss, FU	Gut	2012
29069783	TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression Yao, X, Pham, T, Temple, B, Gray, S, Cannon, C, Hardy, C, Fletcher, K, Ireland, SK, Hossain, A, Chen, R, Abdel-Mageed, AB, Biliran, H	Oncotarget	2017
18794357	Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis Liu, YN, Liu, Y, Lee, HJ, Hsu, YH, Chen, JH	Mol Cell Biol	2008
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15467754	E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma Saito, T, Oda, Y, Kawaguchi, K, Sugimachi, K, Yamamoto, H, Tateishi, N, Tanaka, K, Matsuda, S, Iwamoto, Y, Ladanyi, M, Tsuneyoshi, M	Oncogene	2004
17563753	Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition Julien, S, Puig, I, Caretti, E, Bonaventure, J, Nelles, L, van Roy, F, Dargemont, C, de Herreros, AG, Bellacosa, A, Larue, L	Oncogene	2007
26905733	Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications Serrano-Gomez, SJ, Maziveyi, M, Alahari, SK	Mol Cancer	2016
18524818	Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3 Bruton, RK, Pelka, P, Mapp, KL, Fonseca, GJ, Torchia, J, Turnell, AS, Mymryk, JS, Grand, RJ	J Virol	2008
28135249	The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer He, Y, Northey, JJ, Pelletier, A, Kos, Z, Meunier, L, Haibe-Kains, B, Mes-Masson, AM, Côté, JF, Siegel, PM, Lamarche-Vane, N	Oncogene	2017
33608512	Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer Wang, Y, Sun, Y, Shang, C, Chen, L, Chen, H, Wang, D, Zeng, X	Cell Death Dis	2021
12665527	Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions Peinado, H, Quintanilla, M, Cano, A	J Biol Chem	2003
24293287	The effects of shRNA-mediated gene silencing of transcription factor SNAI1 on the biological phenotypes of breast cancer cell line MCF-7 Lu, Y, Yu, L, Yang, M, Jin, X, Liu, Z, Zhang, X, Wang, L, Lin, D, Liu, Y, Wang, M, Quan, C	Mol Cell Biochem	2014
24297167	Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition Villarejo, A, Cortés-Cabrera, A, Molina-Ortíz, P, Portillo, F, Cano, A	J Biol Chem	2014
19597490	A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition Vincent, T, Neve, EP, Johnson, JR, Kukalev, A, Rojo, F, Albanell, J, Pietras, K, Virtanen, I, Philipson, L, Leopold, PL, Crystal, RG, de Herreros, AG, Moustakas, A, Pettersson, RF, Fuxe, J	Nat Cell Biol	2009
26349968	FOXQ1 promotes esophageal cancer proliferation and metastasis by negatively modulating CDH1 Pei, Y, Wang, P, Liu, H, He, F, Ming, L	Biomed Pharmacother	2015
21285253	Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis Zhang, H, Meng, F, Liu, G, Zhang, B, Zhu, J, Wu, F, Ethier, SP, Miller, F, Wu, G	Cancer Res	2011
23873099	Twist: a molecular target in cancer therapeutics Khan, MA, Chen, HC, Zhang, D, Fu, J	Tumour Biol	2013
22562246	Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer Dong, C, Wu, Y, Wang, Y, Wang, C, Kang, T, Rychahou, PG, Chi, YI, Evers, BM, Zhou, BP	Oncogene	2013
25670862	Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion Nolan, KD, Franco, OE, Hance, MW, Hayward, SW, Isaacs, JS	J Biol Chem	2015
20871592	Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion Kokura, K, Sun, L, Bedford, MT, Fang, J	EMBO J	2010
17130829	Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence Cowger, JJ, Zhao, Q, Isovic, M, Torchia, J	Oncogene	2007
14673164	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex Peinado, H, Ballestar, E, Esteller, M, Cano, A	Mol Cell Biol	2004
26212009	PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer Zhu, G, Li, X, Guo, B, Ke, Q, Dong, M, Li, F	Oncogene	2016
25251281	LIGHT is a crucial mediator of airway remodeling Hung, JY, Chiang, SR, Tsai, MJ, Tsai, YM, Chong, IW, Shieh, JM, Hsu, YL	J Cell Physiol	2015
10655586	The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Cano, A, Pérez-Moreno, MA, Rodrigo, I, Locascio, A, Blanco, MJ, del Barrio, MG, Portillo, F, Nieto, MA	Nat Cell Biol	2000
26549030	Hepatitis C virus core protein interacts with Snail and histone deacetylases to promote the metastasis of hepatocellular carcinoma Nie, D, Shan, X, Nie, L, Duan, Y, Chen, Z, Yang, Y, Li, Z, Tian, L, Gao, Q, Shan, Y, Tang, N	Oncogene	2016
26837418	Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin Zhao, P, Guo, S, Tu, Z, Di, L, Zha, X, Zhou, H, Zhang, X	Acta Biochim Biophys Sin (Shanghai)	2016
23453623	Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer Dong, C, Yuan, T, Wu, Y, Wang, Y, Fan, TW, Miriyala, S, Lin, Y, Yao, J, Shi, J, Kang, T, Lorkiewicz, P, St Clair, D, Hung, MC, Evers, BM, Zhou, BP	Cancer Cell	2013
23298185	The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells Brett, A, Pandey, S, Fraizer, G	Mol Cancer	2013
24280726	CtBP1 overexpression in keratinocytes perturbs skin homeostasis Deng, H, Li, F, Li, H, Deng, Y, Liu, J, Wang, D, Han, G, Wang, XJ, Zhang, Q	J Invest Dermatol	2014
23518002	Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells Ding, SZ, Yang, YX, Li, XL, Michelli-Rivera, A, Han, SY, Wang, L, Pratheeshkumar, P, Wang, X, Lu, J, Yin, YQ, Budhraja, A, Hitron, AJ	Toxicol Appl Pharmacol	2013
26717907	SET8 induces epithelial‑mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 Hou, L, Li, Q, Yu, Y, Li, M, Zhang, D	Mol Med Rep	2016
10655587	The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells Batlle, E, Sancho, E, Francí, C, Domínguez, D, Monfar, M, Baulida, J, García De Herreros, A	Nat Cell Biol	2000