SNAI2 represses CDH1 gene transcription

Stable Identifier
R-HSA-9768484
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
3/5
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SNAI2 represses CDH1 gene transcription
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CDH1 expression is repressed by binding of SNAI2, also known as SLUG or SNAIL2, to E-boxes in the promoter, as demonstrated by EMSA and ChIP in MDCK cells and in synovial sarcoma cell lines (Hayashida et al, 2006; Saito et al, 2006). By a reporter assay, utilizing human CDH1 gene promoter and human SNAI2 (SLUG), it was demonstrated that SNAI2 directly represses CDH1 gene transcription (Hajra et al. 2002). Overexpression of SNAI2 represses transcription of endogenous CDH1 gene in human breast cancer cell lines, and the expression levels of SNAI2 and CDH1 in breast cancer cell lines are inversely correlated (Hajra et al. 2002).
Literature References
PubMed ID Title Journal Year
16943193 Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug

Hayashida, Y, Urata, Y, Muroi, E, Kono, T, Miyata, Y, Nomata, K, Kanetake, H, Kondo, T, Ihara, Y

J Biol Chem 2006
16849535 SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma

Saito, T, Nagai, M, Ladanyi, M

Cancer Res 2006
11912130 The SLUG zinc-finger protein represses E-cadherin in breast cancer

Hajra, KM, Chen, DY, Fearon, ER

Cancer Res 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SNAI2:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
SNAI2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-03-11)
Created
Orlic-Milacic, M  (2022-03-11)
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