Reactome | CTBP1,CTBP2 binds ZEB1

CTBP1,CTBP2 binds ZEB1

Stable Identifier

R-HSA-9765973

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        CTBP1,CTBP2 binds ZEB1 (Homo sapiens)

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ZEB1 forms a complex with CTBP1 (CtBP) (Postigo and Dean 1999; Shi et al. 2003; Ichikawa et a. 2015), as well as related CTBP2 (Postigo and Dean 1999), which is involved in ZEB1-mediated repression of genes involved in epithelial adhesion (Ichikawa et al. 2015, Zou et al. 2024). CTBP1-mediated repression of CDH1 gene transcription involves the recruitment of histone methyltransferases such as EHMT1 (EuHMT) and EHMT2 (G9A), which are part of the CTBP co-repressor complex (Shi et al. 2003). PNN (Pinin), a protein involved in mRNA processing and implicated in the regulation of cell-cell adhesion, can relieve the CTBP1-mediated repression of the CDH1 gene promoter activity (Alpatov et al. 2004). Binding of MCRIP1 to CTBP1 prevents formation of the complex between ZEB1 and CTBP1 (Ichikawa et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25728771	MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP Ichikawa, K, Kubota, Y, Nakamura, T, Weng, JS, Tomida, T, Saito, H, Takekawa, M	Mol Cell	2015
10359772	ZEB represses transcription through interaction with the corepressor CtBP Postigo, AA, Dean, DC	Proc Natl Acad Sci U S A	1999
39318101	BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process Zou, W, Yin, Q, Guo, W, Dong, Z, Guo, Y	Cancer Sci	2024