Reactome | TCF12 represses CDH1 gene transcription

TCF12 represses CDH1 gene transcription

Stable Identifier

R-HSA-9767924

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

3/5

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        TCF12 represses CDH1 gene transcription (Homo sapiens)

General

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While TCF12 was initially reported as a direct activator of the CDH1 gene (Li et al. 2007), subsequent studies identified it as a direct repressor of the CDH1 gene (Lee et al. 2012; Chen et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23386606	Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion Chen, WS, Chen, CC, Chen, LL, Lee, CC, Huang, TS	J Biol Chem	2013
22130667	TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer Lee, CC, Chen, WS, Chen, CC, Chen, LL, Lin, YS, Fan, CS, Huang, TS	J Biol Chem	2012
17202424	Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1 Li, Y, Yang, J, Luo, JH, Dedhar, S, Liu, Y	J Am Soc Nephrol	2007

Participants

Input

CDH1 gene [nucleoplasm] (Homo sapiens)

Output

CDH1 mRNA [cytosol] (Homo sapiens)

Participates

as an event of

Negative Regulation of CDH1 Gene Transcription (Homo sapiens)

This event is regulated

Negatively by

Regulator

TCF12:CDH1 gene [nucleoplasm] (Homo sapiens)

Active Unit

TCF12 [nucleoplasm]

Authored

Orlic-Milacic, M (2022-03-02)

Created

Orlic-Milacic, M (2022-03-02)

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