SNAI1 binds the CDH1 gene

Stable Identifier
R-HSA-9756414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SNAI1 binds the CDH1 gene
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In cancer cells it has been shown that Snail (SNAI1) protein binds the promoter of the E-Cadherin (CDH1) gene and represses expression of CDH1 (Batlle et al. 2000, Maturi et al. 2018, and inferred from mouse homologs). Repression of CDH1 by SNAI1 results in a reduction in CDH1 protein at the plasma membrane that causes loss of contact between epithelial cells during the epithelial to mesenchyme transition that is required for mesoderm formation (inferred from mouse embryos).
Literature References
PubMed ID Title Journal Year
10655587 The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Domínguez, D, Batlle, E, Monfar, M, Baulida, J, Francí, C, Sancho, E, García De Herreros, A

Nat Cell Biol 2000
29729076 Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Morén, A, Maturi, V, Moustakas, A, Heldin, CH, Enroth, S

Mol Oncol 2018
Participants
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Output
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as an event of
Inferred From
Snai1 binds the Cdh1 (E-Cadherin) gene (Mus musculus)
Authored
May, B  (2021-10-10)
Reviewed
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Created
May, B  (2021-10-14)
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