ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter

Stable Identifier
R-HSA-9765850
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter
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MPHOSPH8 (also known as M-phase phosphoprotein 8 or MPP8) binds to the CDH1 gene promoter and represses CDH1 gene expression (Kokura et al. 2010). Binding of MPHOSPH8 to the CDH1 gene promoter is ZEB1 dependent (Sun et al. 2015). MPHOSPH8 was shown to recruit histone deacetylase SIRT1 to ZEB1 at the CDH1 gene promoter, resulting in histone deacetylation, which contributes to CDH1 gene repression (Sun et al. 2015). As MPHOSPH8 binds to histones methylated at H3K9, it is likely that methylation of the CDH1 gene promoter by a histone methyltransferase precedes the recruitment of MPHOSPH8 (Kokura et al. 2010, Sun et al. 2015).
Literature References
PubMed ID Title Journal Year
25870236 MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition

Sun, L, Kokura, K, Izumi, V, Koomen, JM, Seto, E, Chen, J, Fang, J

EMBO Rep 2015
20871592 Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion

Kokura, K, Sun, L, Bedford, MT, Fang, J

EMBO J 2010
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Orthologous Events
ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter (Bos taurus)
ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter (Gallus gallus)
ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-02-16)
Created
Orlic-Milacic, M  (2022-02-16)
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