DNTTIP1 and KDM1A repress CDH1 gene transcription

Stable Identifier
R-HSA-9764827
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
3/5
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DNTTIP1 and KDM1A repress CDH1 gene transcription
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DNTTIP1 (TdIF1) forms a complex with histone demethylase KDM1A (LSD1) at the CDH1 (E cadherin) gene promoter and DNTTIP1 and KDM1A cooperatively repress CDH1 gene transcription. The cooperative repression of CDH1 transcription was assessed by an increase in CDH1 mRNA and protein levels when lung cancer cell lines H1299 and H1975 were treated with anti DNTTIP1 siRNA and KDM1A inhibitor sp2509 (Liu et al. 2021). High expression of DNTTIP1 is a marker of poor prognosis in clear cell renal carcinoma and correlates with low CDH1 expression levels (Wang et al. 2023).
Literature References
PubMed ID Title Journal Year
36636625 High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

Wang, X, Li, W, Lou, N, Han, W, Hai, B, Xiao, W, Zhang, X

Pharmgenomics Pers Med 2023
35008676 TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer

Liu, Q, Xiong, J, Xu, D, Hao, N, Zhang, Y, Sang, Y, Wang, Z, Zheng, X, Min, J, Diao, H, Raphael, J, Maleki Vareki, S, Koropatnick, J, Min, W

Int J Mol Sci 2021
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
KDM1A:DNTTIP1:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
DNTTIP1 [nucleoplasm]
KDM1A [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-02-14)
Created
Orlic-Milacic, M  (2022-02-14)
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